Isolated TRBP polypeptides and uses therefor

Details Isolated TRBP polypeptides and uses therefor Isolated TRBP polypeptides and uses therefor

1999-07-23

2000-04-04

Brusca, John S.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

C07K 1400

Patent

active

060463082

ABSTRACT:
The invention provides nucleic acids encoding a TRBP polypeptide, fragments thereof and homologs thereof The invention also provides TRBP polypeptides, fragments thereof and homologs thereof, and TRBP binding proteins. Methods for treating diseases or conditions characterized by an aberrant TRBP activity, e.g., by administering to the subject a TRBP therapeutic, are also disclosed. Diseases or conditions that can be treated according to the methods of the invention include thyroid-related disorders, metabolic disorders, and diabetes. Also disclosed are methods for predicting whether a subject is at risk of developing a disease associated with an aberrant TRBP activity, by determining, e.g., whether the subject has a genetic lesion in a TRBP gene and assays for identifying TRBP therapeutics.

REFERENCES:
Lee et al., Swissprot 37, Accession #Q15646, Nov. 1997.

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