Isolated toxin associated with Kawasaki syndrome

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues

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530820, C07K 1431

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active

055854656

ABSTRACT:
The invention relates to the isolated toxin associated with Kawasaki syndrome and the bacteria from which these are isolated.

REFERENCES:
patent: 4731245 (1988-03-01), Tsurumizu et al.
patent: 5075236 (1991-12-01), Yone et al.
Schlievert, "Role of Superantigens in Human Disease", J. Infect. Dis. 167: 997-1002 (1993).
Miethke et al., "Pathogenesis of the toxic shock syndrome: T cell mediated lethal shock caused by the superantigen TSST-1", Eur. J. Immunol. 23: 1494-1500 (1993).
Abe et al., "Selective expansion of T cells expressly T-cell receptor variable regions V.beta.2 and B.beta.8 in Kawasaki disease", Proc. Natl. Acad. Sci. USA 89: 4066-4070 (May 1992).
Schulman et al., "Management of Kawasaki syndrome: a concensus statement prepared by North American participants of the Third international Kawasaki Disease Symposium, Tokyo, Japan, Dec. 1988", Pediatr. Infect. Dis. J. 8: 663-665 (1989).
Barsumian et al., "Heterogeneity of Group A Streptococcal Pyrogenic Endotoxin Type B", Infect. & Immunol. 20(2): 512-58 (May 1978).
Leung et al., "Endothelial Cell Activation and High Interleukin-1 Secretion In The Pathogenesis of Acute Kawasaki Disease", Lancer (Dec. 2, 1989), pp. 1289-1303.
Sheagren, "Staphylococcus aureus The Persistent Pathogen", N. Eng. J. Med. 310(21): 1368-1372 (May 24, 1984).
Schlievert et al., "Production of Staphylococcal Pyrogenic Exotoxin Type C: Influence of Physical and Chemical Factors", J. Infect. Dis. 147(2): 236-242 (Feb. 1983).
Schlievert et al., "Purification and Physicochemical and Biological Characterization of a Staphylococcal Pyrogenic Exotoxin", Infect. & Immunol. 23(3): 609-617 (Mar. 1979).
Lee et al., "Nucleotide Sequences and Biological Properties of Toxic Shock Syndrome toxin 1 From Ovine--and Bovine Associated Staphylococcal aureus", J. Infect. Dis. 165: 1056-1063 (1992).
Blomster-Hawtoma et al., "The Nucleotide and Partial Amino Acid Sequence of Toxic Shock Syndrome", J. Biol. Chem. 261: 15783-15786 (1986).

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