Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Animal or plant cell
Patent
1995-03-28
1998-02-10
Witz, Jean C.
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
Animal or plant cell
424 9371, 424 9372, 424 9373, A61K 3528
Patent
active
057166161
ABSTRACT:
Methods of treating patients who are suffering from a disease, disorder or condition characterized by a bone cartilage or lung defect are disclosed. The methods comprising the step of intravenous administration of stromal cells isolated from normal syngeneic individuals or intravenous administration of stromal cells isolated from the patient subsequent to correction if the genetic defect in the isolated cells. Methods of introducing genes into a recipient individual are disclosed. The methods comprise the steps of obtaining a bone marrow sample from either the recipient individual or a matched syngeneic donor, isolating adherent cells from the sample, transfecting the adherent cells that were isolated from the recipient or a matched syngeneic donor with a gene and administering the transfected adherent cells to the recipient individual intravenously. Compositions that comprise isolated stromal cells that include exogenous genes operably linked to regulatory sequences are disclosed.
REFERENCES:
patent: 4608199 (1986-08-01), Caplan et al.
patent: 4609551 (1986-09-01), Caplan et al.
patent: 4620327 (1986-11-01), Caplan et al.
patent: 4904259 (1990-02-01), Itay
patent: 5197985 (1993-03-01), Caplan et al.
patent: 5226914 (1993-07-01), Caplan et al.
patent: 5486359 (1996-01-01), Caplan et al.
Nakagawa, et al., "Prevention of autoimmune inflammatory polyarthritis in male New Zealand black/KN mice by transplantation of bone marrow cells plus bone (stromal cells)." Arthritis and Rheumatism, 36(2), 1993, 263-268.
Anklesaria, P. et al., "Engraftment of a clonal bone marrow stromal cell line in vivo stimulates hematopoietic recovery from total body irradiation", Proc. Natl. Acad. Sci. USA 1987, 84, 7681-7685.
Appelbaum, F.R. et al., "Specific marrow ablation before marrow transplantation using and aminoposphonic acid conjugate .sup.166 Ho-EDTMP", Blood 1992, 80(6), 1608-1613.
Bennett, J.H. et al., "Adipocytic cells cultured from marrow have osteogenic potential", Cell 1991, 99, 131-139.
Beresford, J.N. et al., "Evidence for an adverse relationship between the diffeentiation of adipocytic and osteogenic cells in rat marrow stromal cell cultures", J. of Cell Science 1992, 102, 341-351.
Bienzle, D. et al., "Gene reansfer into hematopoietic cells; long-term maintenance of in vitro activated progenitors without morrow ablation", Proc. Natl. Acad. Sci. USA 1994, 91, 350-354.
Carter, R.F. et al., "Autologus transplantation of canine long-term marrow culture cells genetically marked by retroviral vectors", Blood 1992, 79(2), 356-364.
Castro-Malaspina, H. et al., "Characterization of human bone marrow fibroblast colony-forming cells (CFU-F) and their progeny", Blood 1980, 56(2), 289-301.
Coccia, P.F. et al., "Successful bone-marrow transplantation for infantile malignant osteopetrosis", The New England Journal of Medicine 1980, 302(13), 701-.
Friedenstein, A.J. et al., "Fibroblast precursors in normal and irradiated mouse hematopoietic organs", Exp. Hemat. 1976, 4, 267-274.
Khillan, J.S. et al., "Transgenic mice that express a mini-gene version of the human gene for type I procollagen (COL1A1) develop a phenotype resembling a lethal form of osteogenesis imperfecta", J. of Biological Chemistry 1991, 226(34), 23373-23379.
Kiefer, F. et al., "Fractionation of mouse bone marrow by adherence separates primitive hematopoietic stem cells from in vitro colony-forming cells and spleen colony-forming cells", Blood 1991, 78(10), 2577-2582.
Liesveld, J.L. et al., "Characterization of human marrow stromal cells: role in progenitor cell binding and granulopoiesis", Blood 1989, 73(7), 1794-1800.
Liesveld, J.L. et al., "Adhesive interactions of normal and leukemic human CD34.sup.+ myeloid progenitors: role of marrow stromal, fibroblast, and cytomatrix components", Exp. Hematol. 1991, 19, 63-70.
Morrison, N.A. et al., "Prediction of bone density from vitamin D receptor alleles", Nature 1994, 367, 284-287.
Nakahara, H. et al., "Culture-expanded human periosteal-derived cells exhibit osteochondral potential in vivo", J. of Orthopaedic Research 1991, 9, 465-476.
Niedzwiedzki, T. et al., "Bone healing after bone marrow stromal cell transplantation to the bone defect", Biomaterials 1993, 14(2), 115-121.
O'Hara, M.D. et al., "The development of thermotolerance in bone marrow CFU-S during chronic hyperthermia", Exp. Hematol. 1991, 19, 878-881.
Ohgushi, H. et al., "Repair of bone defects with marrow cells porous ceramic", Acta Orthop Scand 1989, 60(3), 334-339.
Piersma, A.H. et al., "Transplantation of bone marrow fibroblastoid stromal cells in mice via the intravenous route", British Journal of Haematology 1983, 54, 285-290.
Piersma, A.H. et al., "Characterization of fibroblastic stromal cells from murine bone marrow", Exp. Hematol 1985, 13, 237-243.
Simmons, P.J. and Torok-Storb, B., "Identification of stromal cell precursors in human bone marrow by a novel monoclonal antibody, STRO-1", Blood 1991, 78(1), 55-62.
Sokolov, B.P. et al., "Tissue-and development-specific expression in transgenic mice of a type I procollagen (COL1A1) minigene construct with 2.3 kb of the promoter region and 2 kb of the 3'-flanking region. Specificity is independent of the putative regulatory sequences in the first intron", Biochemsistry 1993, 32, 9242-9249.
Stewart, M. et al., "Long-term engraftment of normal and post -5-fluorouracil murine marrow into normal nonmyeloablated mice", blood 1993, 81(10), 2566-2571.
Wakitani, S. et al., "Mesenchymal cell-based repair of large, full-thickness defects of articular cartilage", J. of Bone and Joint Surgery 1994, 76-A(4), 579-592.
Pereira, R. et al., "Transgenic Mice Expressing a Partially Deleted Gene for Type I Procollagen (COL1A1)", J. Clin. Invest. 1993, 91, 709-716.
Leeper Dennis B.
O'Hara Michael D.
Pereira Ruth F.
Prockop Darwin J.
Thomas Jefferson University
Witz Jean C.
LandOfFree
Isolated stromal cells for treating diseases, disorders or condi does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Isolated stromal cells for treating diseases, disorders or condi, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Isolated stromal cells for treating diseases, disorders or condi will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2074999