Chemistry: molecular biology and microbiology – Virus or bacteriophage – except for viral vector or...
Patent
1995-06-05
1998-05-19
Ketter, James
Chemistry: molecular biology and microbiology
Virus or bacteriophage, except for viral vector or...
4352402, C12N 701
Patent
active
057534888
ABSTRACT:
An isolated stealth virus that is positively correlated with chronic fatigue syndrome is provided from a patient having a disease. Examples of diseases the patient may have include multiple sclerosis, unexplained encephalopathy, acute encephalopathy, psychiatric disorder, Alzheimer's disease, fibromyalgia, myositis, muscle neuritis, chronic pain syndrome, salivary gland enlargement, autoimmune disease, and unexplained hepatitis. A vaccine having an isolated stealth virus or antigen is also provided.
REFERENCES:
patent: 4629783 (1986-12-01), Cosand
patent: 4683195 (1987-07-01), Mullis et al.
patent: 4683202 (1987-07-01), Mullis
patent: 4889818 (1989-12-01), Gelfand et al.
Plotkin et al., "Protective effects of Towne Cytomegalovirus vaccine against low-passage cytomegalovirus administered as a challenge", J. Infect. Dis. 159(5): 860-865, May 1989.
Cowley et al., "A chronic fatigue cover-up", Newsweek, Apr. 22, 1996, p. 62, Apr. 1996.
Ehrlich et al., "Detection of Human T-Cell Lymphoma-Leukemia Viruses," PCR Protocols: A Guide to Methods and Applications, Ch. 39, pp. 325-336 (1990).
Feinberg and Vogelstein, "A technique for radiolabeling DNA restriction endocnuclease fragment to high specific activity," Anal. Biochem. 137:266-267 (1984).
Freshney, "Ch. 10--Maintenance of the Culture-Cell Lines," Culture of Animal Cells: A Manual of Basic Technique, Alan R. Liss, Inc., New York, pp. 127-136 (1987).
Gupta and Vayuvegula, "A Comprehensive Immunological Analysis in Chronic Fatigue Syndrome," Scand. J. Immunol. 33:319-327 (1991).
Ham, R.G., "An Improved Nutrient Solution for Diploid Chinese Hamster and Human Cell Lines," Exp. Cell Research 29:515-526 (1963).
Ho, M., Cytomegalovirus: Biology and Infection, 2nd ed., pp. 75-76, Plenum Medical Book Company, New York, N.Y. (1991).
Holmes, G.P., "Defining the Chronic Fatigue Syndrome," Reviews of Infectious Diseases 13(Suppl. 1):553-555 (1991).
Holmes et al., "Chronic Fatigue Syndrome: A Working Case Definition," Annals of Internal Medicine 108:387-389 (1988).
Iscove and Melchers, "Complete Replacement of Serum By Albumin, Transferrin and Soybean Lipid in Cultures of Lipopolysaccharide-Reactive B Lymphocytes," J. Exp. Med. 147:923-933 (1978).
Kendell, R.E., "Chronic Fatigue Viruses and Depression," The Lancet 337:160-161(1991).
Landay et al., "Chronic Fatigue Syndrome: Clinical Condition Associated with Immune Activation," The Lancet 338:707-712 (1991).
Martin, W.J., "Ch. 27--Detection of viral Related Sequences in CFS Patients Using the Polymerase Chain Reaction," The Clinical and Scientific Basis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, pp. 278-281, Hyde et al. eds., The Nightingale Research Foundation, Ogdensburg, New York (1992).
Martin, W.J., "Ch. 34--Viral Infekction in CFS Patients," The Clinical and Scientific Basis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, pp. 325-3271, Hyde et al. eds., The Nightingale Research Foundation, Ogdensburg, New York (1992).
Martin et al., "Cytomegalovirus-Related Sequence in an Atypical Cytopathic Virus Repeatedly Isolated from a Patient with Chronic Fatigue Syndrome," The American Journal of Pathology 145(2):440-451 (1994).
Niks and Otto, "Towards an Optimized MTT Assay," Immunological Methods 130:149-151 (1990).
Palca, J., "On the Track of an Elusive Disease," Science 254:1726-1728 (1991).
Palca, J., "Does a Retrovirus Explain Fatigue Syndrome Puzzle?" Science 249:1240-1241 (1990).
Rethwilm et al., "Infectious DNA of the Human spumaretrovirus," Nucleic Acids Research 18:733-738 (1990).
Sanger et al., "DNA sequencing with chain-terminating inhibitors," Proc. Natl. Acad. Sci. USA 74:5463-5467 (1977).
Schirmer et al., "Differentiation Between Two Distinct Classes of Viruses Now Classified as Human Herpesvirus 6," Proc. Natl. Acad. Sci. USA 88:5922-5926 (1991).
Shafran, S.D., "The Chronic Fatigue Syndrome," The American Journal of Medicine 90:730-738 (1991).
Shepherd, C., "Myalgic Encephalomyelitis--Is It a Real Disease?" The Practitioner 233:41-46 (1989).
Wang et al., "Single primer-mediated polymerase chain reaction: application in cloning of two different 51-untranslated sequences of acidic fibroblast growth factor MRNA," DNA Cell Biol. 10:771-777 (1991).
Welch et al., "Cytomegalovirus Homologs of Ceullar G Protein-Coupled Receptor Genes Are Transcribed," J.Virology 65:3915-3918 (1991).
Werner, J., "Isolation of Foamy Virus From Patients with De Quervain Thyroiditis," Lancet II:258-259 (1979).
Yousef et al., "Chronic Enterovirus Infection in Patients with Postviral Fatigue Syndrome," Lancet i:146-150 (1988).
Ablashi et al., "Genomic Polymorphism, Growth Properties and Immunologic Variations in Human Herpesvirus 6 Isolates," Virology 184:545-552 (1991).
Ablashi et al., "Utilization of Human Hematopoietic Cell Lines For the Propagation and Characterization of HBLV (Human Herpesvirus 6)," Int. J. Cancer 42:787-791 (1988).
Ada, "Vaccines" in Fundamental Immunology, 2nd edit., Paul ed., Raven Press, Ltd., New York, pp. 985-1032 (1989).
Archard et al., "Postviral Fatigue Syndrome: Persistence and Enterovirus RNA in Muscle and Elevated Creatine Kinase," The Royal Society of Medicine vol.81 (1988).
Buchwald et al., "A Chronic Illness Characterized by Fatigue, Neurologic and Immunologic Disorders and Active Human Herpesvirus Type 6 Infection," Annals of Internal Medicine 116:103-113 (1992).
Chee et al., "Analsyis of the Protein Coding Content of the Sequence of Human Cytomegalovirus Strain AD169," Current Topics in Microbiololgy and Immunology 154:126-169 (1990).
Cohen et al., "Okadaic Acid: A New Probe for the Study of Cellular Regulation," TIBS 15:98-102 (1990).
Dale et al., "The Inoue-Melnick Virus, Human Herpesvirus Type 6, and the Chronic Fatigue Syndrome," Annals of Internal Medicine 110:92-93 (1989).
Dale et al., "Chronic Fatigue Syndrome: Lack of Association with Hepatitis C Virus Infection," J. Medical Virology 34:119-121 (1991).
DeFreitas et al., "Retroviral sequences related to human T-lymphotropic virus type II in patients with chronic fatigue immune dysfunction syndrome," Chemical Abstracts 114:No. 205331c (1991).
DeFreitas et al., "Retroviral Sequences Related To Human T-lymphotropic Virus Type II in Patients with Chronic Fatigue Immune Dysfunction Syndrome," Proc. Natl. Acad. Sci. USA 88:2922-2926 (1991).
Demitrack et al., "Evidence for Impaired Activation of the Hypothalamic-Pituitary-Adrenal Axis in Patients with Chronic Fatigue Syndrome," Journal of Clinical Endocrinology and Metabolism 73:1224-1234 (1991).
DiLuca et al., "The Replication of Viral and Cellular DNA in Human Herpesvirus 6-Infected Cells," Virology 175:199-210 (1990).
Ketter James
Yucel Iran
LandOfFree
Isolated stealth viruses and related vaccines does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Isolated stealth viruses and related vaccines, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Isolated stealth viruses and related vaccines will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1852169