Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2008-05-27
2008-05-27
Mondesi, Robert B. (Department: 1656)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C435S069100, C435S419000, C435S468000
Reexamination Certificate
active
11189342
ABSTRACT:
Disclosed is an isolated protein from the Chinese medicinal herb, Yuzhu,Polygonatum odoratum(Liliaceae). The protein disclosed is an effective agent showing potent antiviral activities while demonstrating antiproliferative effect on HL-60 leukemia and MCF-7 breast cancer cell lines in vitro. A method of obtaining the target protein and use thereof are also provided.
REFERENCES:
patent: 1537943 (2004-10-01), None
patent: 1557842 (2004-12-01), None
patent: 1562350 (2005-01-01), None
Appendix A—Sequence alignment of SEQ ID No. 1 and van Damme U44775 from Plant Mol. Biol. 1996 reference, no date.
Bowie et al., Deciphering the Message in Protein Sequences: Tolerance to Amino Acid Substitutions. Science. 1990. vol. 247, pp. 1306-1310.
Wells, J.A., Additivity of Mutational Effects in Proteins. Biochemistry. 1990, vol. 29, No. 37, pp. 8509-8517.
Appendix B—Sequence alignment of SEQ ID No. 1 and Bao et al. from AF521656, no date.
GenBank accession No. AF521656, Jul. 14, 2002, Bao, J. et al. “Gene cloing ofPolygongtum crytronemaHua lectin II”.
GenBank accession No. U44775, Sep. 4, 1996, Van Damme, E. J. et al., “Molecular cloning of the lectin and a lectin-related protein from common Solomon's seal”.
Koike, T., Titioni, K., Suzuki, M., Beppu, H., Kuzuya, H., Maruta, K., Shimp, K., and Fujita, K. 1995. The complete amino acid sequence of a mannose-binding lectinf from “Kidachi aloe” (aloearborescensvar.natalensisBerger).Biochemical and Biophysical Research Communication, 214: 163-170.
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Van Damme, E.J.M., Barre, A., Rouge, P., Van Leuven, F., Balzarini, J. and Peumans, W.J. 1996. Molecular cloning of the lectin and a lectin-related protein from common Solomon's seal (Polygonatum multiflorum).Plant Molecular Biology, 31: 657-672.
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Ooi Linda Shiou Mei
Ooi Vincent Eng Choon
Sun Samuel Sai Ming
Desai Anand U
Knobbe Martens Olson & Bear LLP
Mondesi Robert B.
The Chinese University of Hong Kong
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