Isolated protein which binds to A33 antibody, and peptides corre

Details Isolated protein which binds to A33 antibody, and peptides corre Isolated protein which binds to A33 antibody, and peptides corre

1996-02-02

1998-01-27

Jones, W. Gary

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

4241841, 4241851, 530300, 530324, 530326, 530327, 530328, C07K 1400, A61K 3900, A61K 3938, A61K 3800

Patent

active

057123691

ABSTRACT:
This invention relates to isolated protein and to peptides which are found on the surface of colon cells and colon cancer cells, as well as to nucleic acid molecules encoding said protein and peptides. The protein and peptides bind to tumor-associated antibodies, such as mAb A33. The monomeric protein has a molecular weight of about 43 kD as determined by SDS gel electrophoresis under non-reducing conditions. In addition, this invention relates to the use of said nucleic acid molecules, protein, in monomeric or multimeric form, and to antibodies to said peptides in diagnostic, screening and therapeutic methods. This invention further relates to antibodies specific for said protein, in monomeric or multimeric form, and to antibodies to said peptides.

REFERENCES:
Welt et al. (1994) J. Clin. Oncol. 12:1561-71.
King et al. (1995) Br. J. Cancer 72:1364-72.
Daghighian et al. (1996) J. Nucl. Med. 37:1052-57.

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