Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of...
Patent
1995-05-12
1997-10-14
Rollins, John W.
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
C12N 500
Patent
active
056771746
ABSTRACT:
Isolated porcine pancreatic cells, isolated populations of such cells and methods for isolating and using the cells to treat subjects with diseases characterized by insufficient insulin activity are described. The porcine pancreatic cells are preferably non-insulin-secreting porcine pancreatic cell having the ability to differentiate into an insulin-secreting cell upon introduction into a xenogeneic subject, such as a human subject. Such cells include embryonic porcine pancreatic cells obtained from embryonic pigs between about day 31 and day 35 of gestation. The porcine pancreatic cells can be modified to be suitable for transplantation into a xenogeneic subject, for example, by altering an antigen (e.g., an MHC class I antigen) on the cell surface which is capable of stimulating an immune response against the cell in the subject (e.g., by contact with an anti-MHC class I antibody, or a fragment or derivative thereof). The isolated porcine pancreatic cells of the invention can be used to treat diseases characterized by insufficient insulin activity, e.g., Type I and Type II diabetes, by administering the cells to a subject having such a disease.
REFERENCES:
patent: 5147784 (1992-09-01), Peault
Groth, C.G. et al. (1993) "Transplantation of Porcine Fetal Islet-Like Cell Clusters Into Eight Diabetic Patients" Transplantation Proceedings 25(1 ): p. 970.
Andersson, A. et al. (1992) "Transplantation of Porcine Fetal Islet-Like Cell Clusters to Three Diabetic Patients" Transplantation Proceedings 24(2): pp. 677-678.
Bjoersdorff, A. et al. (1992) "Microbiologic Screening As A Preparatory Step For Clinical Xenografting of Porcine Fetal Islet-Like Cell Clusters" Transplantation Proceedings 24(2): pp. 674-676.
Holgersson, J. et al. (1992) "Carbohydrate Specificity of Human Immunoglobulin-M Antibodies With Pig Lymphocytotoxic Activity" Transplantation Proceedings 24(2): 605-608.
Kaiser, N. et al., "Monolayer Culture of Adult Rat Pancreatic Islets on Extracellular Matrix; Long Term Maintenance of Differentiated B-Cell Function" Endocrinology, vol. 123, No. 2, pp. 834-840 1988.
Korsgren, O. et al.(1989) "Effects of Culture Conditions on Formation and Hormone Content of Fetal Porcine Isletlike Cell Clusters" Diabetes 38(Suppl. 1 ): 209-212.
Korsgren, O. et al.(1988) "Large-Scale Production of Fetal Porcine Pancreatic Isletlike Cell Clusters" Transplantation 45(3): 509-514.
Kumagai-Braesch, M. et al. (1992) "Immune Response of Diabetic Patients Against Transplanted Porcine Fetal Islet Cells" Transplantation Proceedings 24(2): 679-680.
Lacey, P.E. et al. (1979) "Prolongation of Islet Allograft Survival Following in vitro Culture (24.degree. C.) and a Single Injection of ALS" Science 204:312-313.
Markmann, J.R. et al. (1992) "Indefinite Survival of MHC Class I-Deficient Murine Pancreatic Islet Allografts" Transplantation 57(6): 783-788.
Montesano, R. et al.(1983) "Collagen Matrix Promotes Reorganization of Pancreatic Endocrine Cell Monolayers into Islet-like Organoids" Journal of Cell Biology 97: 935-939.
Munn, S.R. and C. Marjoribanks (1992) "Abrogation of Islet Immunogenicity Using an Anti-MHC Class I Monoclonal Antibody" Transplantation Proceedings. 24(3): 1038-1039.
Munn, S.R. and C. Marjoribanks (1992) "Masking Donor Histocompatibility Complex Class I Antigens on Allogenic Islets" Transplantation Proceedings 24(6): 2857.
Nielsen, J.H., "Effects of Growth Hormone, Prolactin, and Placental Lactogen on Insulin Content and Release, and Deoxyribonucleic Acid Synthesis in Cultured Pancreatic Islets" Endocrinology, 110(2):. 600-606.
Nielsen, J.H. (1989) "Growth Hormone is a Growth Factor for the Differentiated Pancreatic .beta.-Cell" Molecular Endocrinolog 3(1): 165-173.
Osorio, R.W. et al. (1994) "Prolongation of in vivo Mouse Islet Allograft Survival by Modulation of MHC Class I Antigen" Transplantation 57(6): 783-788.
Otonkoski, T. et al. (1993) "Nicotinamide Is a Potent Inducer of Endocrine Differentiation in Cultured Human Fetal Pancreatic Cells" J. Clin. Invest. 92: 1459-1466.
Pittman, K. et al.(1994) "Use of Discordant Islet Xenografts for the Treatment of Type II Diabetes" Transplantation Proceedings 26(3): 1135-1137.
Pyzdrowski, K.L. et al. (1992) "Preserved Insulin Secretion and Insulin Independence in Recipients of Islet Autografts" New England Journal of Medicine 327(4): 220-226.
Rabinovitch, A. et al. (1983) "Growth Hormone Stimulates Islet B-Cell Replication in Neonatal Rat Pancreatic Monolayer Cultures" Diabetes 32: 307-312.
Roark, J.H. et al. (1992) "Prolongation of Rat Pancreatic Islet Allograft Survival by Anti-CD.sub.2 Monoclonal Antibody Treatment" Transplantation 54(6): 1098-1103.
Rosengard, B.R. et al. (1992) "Induction of Specific Tolerance to Class I-Disparate Renal Allografts in Miniature Swine With Cyclosporine" Transplantation 54(3): 490-497.
Sasaki, N. et al. (1984), "Fetal Pancreas Transplantation in Miniature Swine" Transplantation 38(4): 335-340.
Satake, M. et al. (1994) "Kinetics and character of xenoantibody formation in diabetic patients transplanted with fetal porcine islet cell clusters" Xenotransplantation 1:24-35.
Shishko, P.I. et al. (1992), "Islet Cell Transplantation in Induction and Prolongation of Insulin-Dependent Diabetes Remission" Transplantation Proceedings 24(6): 3040.
Simeonovic, C.J. and K.J. Lafferty (1982), "The Isolation and Transplantation of Foetal Mouse Proislets" Aust. J. Exp. Biol. Med. Sci., 60(4): 383-390.
Simeonovic, C.J. et al. (1990), "Antibody-Induced Rejection of Pig Proislet Xenografts in CD4.sup.+ T Cell-Depleted Diabetic Mice" Transplantation, 50(4):657-662.
Simeonovic, C.J. et al. (1990), "Effect of GK1.5 Monoclonal Antibody Dosage on Survival of Pig Proislet Xenografts in CD4.sup.+ T Cell-Depleted Mice" Transplantation, 49(5): 849-856.
Soon-Shiong, P. et al (1993), "Long-term reversal of diabetes by the injection of immunoprotected islets" Proc. Natl. Acad. Sci. USA, 90:5843-5847.
Sorenson, R.L. et al.(1987), "Prolactin (in Vitro) Decreases the Glucose Stimulation Threshold, Enhances Insulin Secretion, and Increases Dye Coupling among Islet B Cells" Endocrinology, 121(4):1447-1453.
Stock, P.G. et al., "Modulation of MHC Class I Antigen Decreases Pancreatic Islet Immunogenicity" Journal of Surgical Research, 46(4): 317-321.
Swenne, I.(1982), "The Role of Glucose in the In Vitro Regulation of Cell Cycle Kinetics and Proliferation of Fetal Pancreatic B-Cells" Diabetes, 31:754-760.
Swenne, I. et al.(1988), "Effects of Platelet-Derived Growth Factor and Somatomedin-C/Insulin-Like Growth Factor I on the Deoxyribonucleic Acid Replication of Fetal Rat Islets of Langerhans in Tissue Culture" Endocrinology, 122(1): 214-218.
Thivolet, C.H. et al.(1985), "Morphological and Functional Effects of Extracellular Matrix on Pancreatic Islet Cell Cultures" Experimental Cell Research, 159:313-322.
Wahoff, D.C. et al.(1994), "lntraperitoneal Transplantation of Microencapsulated Canine Islet Allografts With Short-Term, Low-Dose Cyclosporine for Treatment of Pancreatectomy-Induced Diabetes in Dogs" Transplantation Proceedings, 26(2): 804.
Whittaker, P.G. and K.W. Taylor (1980), "Direct Effects of Rat Growth Hormone on Rat Islets of Langerhans in Tissue Culture" Diabetologia, 18; 323-328.
Wilson, J.D. et al.(1989), "Role of CD4.sup.+ T-Lymphocytes in Rejection by Mice of Fetal Pig Proislet Xenografts" Diabetes, 38 (Suppl. 1), 217-219.
Yoneda, K. et al.(1989), "Fetal Pancreas Transplantation in Miniature Swine, II. Survival of Fetal Pig Pancreas Allografts Cultured at Room Temperature" Diabetes, 38 (Suppl. 1): 213-216.
Dinsmore, J.H. and J. Ratliff (1994) "Isolation, Growth, Differentiation, and Transplantation of Pig Fetal Pancreatic Cells" Molecular Biology of the Cell 5(Suppl.): 350A (Abstract No. 2032).
Korsgren, O. et al. (1991) "Functional and morphological differentiation of fetal porcine islet-like cell clusters after transplantation into nude mice" Diabetologia 34: 379-386.
Korsgren, O. et al. (1993) "Pretreatment of fetal porcine pancreas in culture with nicotinamide accelerates reversal of diabetes after transplantation to nude mice" Sur
Diacrin Incorporated
Rollins John W.
Silveri Jean M.
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