Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1997-11-18
1999-09-28
Elliott, George C.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
435193, C07K 1400, C12N 900
Patent
active
059590785
ABSTRACT:
Isolated nucleic acid molecules encoding polysialyl transferases, and the polysialyl transferases themselves are disclosed. SEQ ID NOS: 1, 2, 7 and 8 present examples of these. The nucleic acid molecules and the proteins can be used diagnostically or therapeutically. Additionally, antisense oligonucleotides and antibodies are described, which can also be used diagnostically or therapeutically.
REFERENCES:
patent: 5457035 (1995-10-01), Baum et al.
Nara et al., Expression cloning of a CMP-NeuAc:NeuAc(alpha)2-3Gal(beta)1-4Glc(beta)1-1'Cer(alpha)2,8-sialytrans ferase (GD3 synthase) from human melanoma cells, Proc. Natl. Acad. Sci., vol. 91, pp. 7952-7956 Aug. 1994.
Ngo et al., Computational complexity, protein structure prediction, and the Levinthal paradox, The Protein Folding Problem and Tertiary Structure Prediction, pp. 433-440 1994.
Eckhardt Matthias
Fukuda Minoru
Gerardy-Schahn Rita
Nakayama Jun
Boehringer Mannheim GmbH
Elliott George C.
Wang Andrew
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