Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of...
Reexamination Certificate
2003-10-02
2008-12-02
Bunner, Bridget E (Department: 1647)
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
C435S320100, C435S252300, C536S023100, C536S023500, C536S024100, C530S350000
Reexamination Certificate
active
07459309
ABSTRACT:
The invention relates to an isolated nucleic acid encoding a eukaryotic Survival of Motor Neuron-Interacting Protein 1 (SIP1), compositions comprising SIP1 and SIP1 and the spinal muscular atrophy (SMA) disease gene product Survival of Motor Neuron protein (SMN), and diagnostic and therapeutic assays directed to SMA. The invention also relates to another protein that specifically interacts with SMN and is a component of gems, designated Gemin3, and the nucleic acid encoding the protein. Additionally, the invention relates to a novel cell line wherein the endogenous SMN genes have been deleted and where an exogenous nucleic acid encoding SMN has been inserted into the cell such that expression of SMN in the cell is under the control of an inducible promoter. This novel cell line provides a stable genetic system for the study of SMA and for the development of SMA therapeutics.
REFERENCES:
patent: 4160452 (1979-07-01), Theeuwes
patent: 4256108 (1981-03-01), Theeuwes
patent: 4265874 (1981-05-01), Bonsen et al.
patent: 5023243 (1991-06-01), Tullis
patent: 5168053 (1992-12-01), Altman et al.
patent: 5190931 (1993-03-01), Inouye
patent: 6160010 (2000-12-01), Uckun et al.
Liu et al. Genbank Accession No. AF027150, Oct. 30, 1997.
Skolnick et al. From genes to protein structure and function: novel applications of computational approaches in the genomic era. Trends in Biotech 18(1): 34-39, 2000.
Bork, A. Powers and pitfalls in sequence analysis: the 70% hurdle. Genome Res 10: 398-400, 2000.
Doerks et al. Protein annotation: detective work for function prediction. Trends in Genetics 14(6): 248-250, 1998.
Smith et al. The challenges of genome sequence annotation or “The devil is in the details”. Nature Biotech 15: 1222-1223, 1997.
Brenner, S.E. Errors in genome function. Trends in Genetics 15(4): 132-133, 1999.
Bork et al. Go hunting in sequence databases but watch out for the traps. Trends in Genetics. 12(10): 425-427, 1996.
Wells. J.A. Additivity of mutational effects in proteins. Biochemistry 29 (37): 8509-8517, 1990.
Ngo et al. Computational complexity, protein structure prediction, and the Levinthal paradox. The Protein Folding Problem and Tertiary Structure Prediction, pp. 492-495, 1994.
Kaufman et al. Blood 94: 3178-3184, 1999.
Wang et al. Rapid analysis of gene expression (RAGE) facilitates universal expression profiling. Nucleic Acids Res 27(23): 4609-4618, 1999.
Phillips, A., The challenge of gene therapy and DNA delivery. J Pharm Pharmacology 53: 1169-1174, 2001.
Fischer et al. The SMN-SIP1 complex has an essential role in spliceosomal snRNP biogenesis. Cell 90: 1023-1029, 1997.
Altschul et al., 1990, J. Mol. Biol. 215:403-410.
Andrade et al., 1991, J. Exp. Med. 173:1407-1419.
Andrade et al., 1993, Proc. Natl. Acad. Sci. USA 90:1947-1951.
Arenas and Abelson, 1997, Proc. Natl. Acad. Sci. USA 94:11798-11802.
Barbas, 1995, Nature Medicine 1:837-839.
Bohmann et al., 1995, J. Cell Biol. 131:817-831.
Bohmann et al., 1995, J. Cell Sci. 19:107-113.
Branlant et al., 1982, EMBO J. 1:1259-1265.
Brzustowicz et al., 1990, Nature 344:540-541.
Burghes, 1997, Am. J. Hum. Genet. 61:9-15.
Burton et al., 1994, Adv. Immunol. 57:191-280.
Bussaglia et al., 1995, Nat. Genet. 11:335-337.
Carmo-Fonseca et al., 1991, EMBO J. 10:195-206.
Cech et al., 1992, J. Biol. Chem. 267:17479-17482.
Cech, 1988, J. Amer. Med. Assn. 260:3030.
Chang et al., 1995, Am. J. Hum. Genet. 57:1503-1505.
Choi and Dreyfuss, 1984, J. Cell. Biol. 99:1997-2004.
Cobben et al., 1995, Am. J. Hum. Genet. 57:805-808.
Company et al., 1991, Nature 349:487-493.
Coovert et al., 1997, Hum. Mol. Gen. 6:1205-1214.
Cranage et al., 1986, EMBO J. 5:3057-3063.
Cross et al., 1994, Nature Genet. 6:236-244.
Czeizel and Hamular, 1989, J. Med. Genet. 26761-763.
de Kruif et al. 1995, J. Mol. Biol. 248:97-105.
DeRobertis, 1983, Cell 32:1021-1025.
Dignam et al., 1983, Nucl. Acids Res. 11:1475-1489.
Dreyfuss et al., 1993, Ann. Rev. Biochem. 62:289-321.
Dreyfuss, 1984, J. Cell. Biol. 99:1997-2004.
Feeney et al., 1989, J. Biol. Chem. 264:5776-5783.
Fischer and Luhrmann, 1990, Science 249:786-790.
Fischer et al., 1993, EMBO J. 12:573-583.
Fisher et al., 1985, Cell 42:751-758.
Fischer et al., 1995, Cell 82:475-483.
Gall et al., 1995, Dev. Genet. 16:25-35.
Gennarelli et al., 1995, Biochem. Biophys. Res. Commun. 213:342-348.
Gu et al., 1997, Thrombosis and Haemostates 77:755-759.
Hahnen et al., 1995, Hum. Mol. Genet. 4:1927-1933.
Hahnen et al., 1996, Am. J. Hum. Genet. 59:1057-1065.
Hamm and Lamond, 1998, Curr. Biol. 8:R532-R534.
Hamm et al., 1990, Cell 62:569-577.
Hampel et al., 1989, Biochemistry 28:4929-4933.
Hasselhoff, 1988, Nature 334:585.
Herrmann et al., 1995, EMBO J. 14:2076-2088.
Huang and Spector, 1992, Proc. Natl. Acad. Sci. USA 89:305-308.
Jarmolowski and Mattaj, 1993, EMBO J. 12:223-232.
Jarmolowski et al., 1994, J. Cell Biol. 124:627-635.
Kay et al., 1997, Proc. Natl. Acad. Sci. U.S.A. 94:12744-12746.
Konarska et al., 1984, Cell 38:731-736.
Konarska, 1989, Methods Enzymol. 180:442-453.
Krainer, 1988, Nucleic Acids Res. 16:9415-9429.
Lamond and Carmo-Fonesca, 1993, Trends Cell Biol. 3:198-204.
Lamond and Earnshaw, 1998, Science 280:547-553.
Lefebvre et al., 1995, Cell 89:155-165.
Lefebvre et al., 1997, Nature Genet. 16:265-269.
Lehmeier et al., 1994, Proc. Natl. Acad. Sci. USA 91:12317-12321.
Liu and Dreyfuss, 1996, EMBO J. 15:3555-3565.
Liu et al., 1996, Cold Spring Harbor Symp. Quant. Biol. 61:689-697.
Liu et al., 1997, Cell 90:1013-1021.
Lorson et al., 1998, Nature Genet. 19:63-66.
Luhrmann et al., 1990, Biochim. Biophys. Acta Gene Struct. Express. 1087:265-292.
Mann and Wilm, 1994, Analytical Chemistry 66:4390-4399.
Marcus-Sakura, 1988, Anal. Biochem. 172:289.
Marks et al., 1991, J. Mol. Biol. 222:581-597.
Matera and Frey, 1998, Am. J. Hum. Genet. 63:317-321.
Matera and Ward, 1993, J. Cell Biol. 121:715-727.
Mattaj and DeRobertis, 1985, Cell 40:111-118.
Moore et al., 1993, In: The RNA World, pp. 303-358.
Mylin et al., 1994, Genetics 137:689-700.
Nakielny and Dreyfuss, 1996, J. Cell. Biol. 134:1365-1373.
Neuman de Vegvar and Dahlberg, 1990, Mol. Cell. Biol. 10:3365-3375.
Noble and Guthrie, 1996, Genetics 143:67-80.
Noble and Guthrie, 1996, EMBO J. 15:4368-4379.
Ohno and Shimura, 1996, Genes & Dev. 10:997-1007.
O'Keefe et al., 1994, J. Cell Biol. 124:249-260.
Padgett et al., 1983, Cell 35:101-107.
Pearn, 1973, J. Med. Genet. 10:260-265.
Pinol-Roma et al., 1988, Genes Dev. 2:215-227.
Raghunathan and Guthrie, 1998, Science 279:857-860.
Raker et al., 1996, EMBO J. 15:2256-2269.
Raska et al., 1990, J. Struct. Biol. 104:120-127.
Roberts et al., 1970, Arch. Dis. Child. 45:33-38.
Rodrigues et al., 1995, Hum. Mol. Genet. 4:631-634.
Roth, 1995, Curr. Opin. Cell Biol. 7:325-328.
Raghunathan et al., 1998, Science 279:857-860.
Salazar Grueso et al., Neuroreport. 2:505-508.
Schrank et al., 1997, Proc. Natl. Acad. Sci. 94:9920-9925.
Shevchenko et al., 1996, Anal. Chemistry 68: 850-858.
Singh and Reddy, 1989, Proc. Natl. Acad. Sci. USA 86:8280-8283.
Siomi and Dreyfuss, 1995, J. Cell Biol. 129:551-560.
Staley and Guthrie, 1998, Cell 92:315-326.
Talbot et al., 1997, Hum. Mol. Genet. 6:497-500.
Terns et al., 1993, Genes Dev, 7:1898-1906.
Trupp et al., Nature 381:785-788.
Tuszynski et al., 1988, Blood, 72:109-115.
Velasco et al., 1996, Hum. Mol. Genet. 5:257-263.
Verschueren et al., 1999, J. Biol. Chem. 274:20489-20498.
Wassarman and Steitz, 1991, Mol. Cell. Biol. 11:3432-3445.
Weintraub, 1990, Scientific American 262:40.
Wilm and Mann, 1996, Anal. chem. 68:1-8.
Wright et al., 1992, Critical Rev. Immunol. 12:125-168.
Zeller et al., 1983, Cell 32:425-434.
Zeng et al., 1997, EMBO J. 16:1401-1412.
Zhang et al., 1998, Mol. Cell. Biol. 18:676-684.
Zieve and Sauterer, 1990, Crit. Rev. Biochem. Mol. Biol. 25:1-46.
Charroux Bernard
Dreyfuss Gideon
Fischer Utz
Liu Qing
Pellizzoni Livio
Bunner Bridget E
Drinker Biddle & Reath LLP
The Trustees of the University of Pennsylvania
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