Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1995-07-17
1998-08-18
Kemmerer, Elizabeth C.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
536 231, 536 235, 536 243, 4353201, 435326, 4351723, 4352523, C07K 14435, C12N 121, C12N 1512
Patent
active
057957355
ABSTRACT:
The present invention provides novel PKA-binding polypeptides, nucleic acids that encode the polypeptides and antibodies specifically immunoreactive with the polypeptides.
REFERENCES:
patent: 4568649 (1986-02-01), Bertoglio-Matte
patent: 4766046 (1988-08-01), Abra et al.
patent: 5169637 (1992-12-01), Lenk et al.
patent: 5180713 (1993-01-01), Abra
patent: 5185154 (1993-02-01), Lasic et al.
patent: 5204112 (1993-04-01), Hope et al.
patent: 5252263 (1993-10-01), Hope et al.
patent: 5283173 (1994-02-01), Fields et al.
Kuroda et al. Cell 66:935-947, 1991.
Lin et al. J. Biol. Chem. 270:27804-27811, 1995.
Trendelenburg et al. Biochem. Biophys. Res. Commun. 225:313-319, 1996.
Aldape et al., "Charged Surface Residues of FKBP12 Participate in Formation of the FKBP12-FK506-Calcineurin Complex*", J. Biol. Chem. 267:16029-16032 (1992).
Allen et al., "Cyclosporin: A Therapy for Wegner's Granulomatosis" in ANCA-Associated Vasculitides: Immunological and Clinical Aspects, Gross (ed.) New York: Plenum Press (1993), pp. 473-476.
Belldegrun et al., "Interferon-.alpha. Primed Tumor-Infiltrating Lymphocytes Combined with Interleukin-2 and Interferon-.alpha. as Therapy for Metastatic Renal Cell Carcinoma", J. Urol. 150:1384-1390 (1993).
Boudet et al., "UV-treated polystyrene microtitre plates for use in an ELISA to measure antibodies aginst synthetic peptides" J.Immunol.Meth. 142:73-82 (1991).
Bougneres et al., "Factors Associated With Early Remission Of Type I Diabetes In Children Treated With Cyclosporine", N.Eng.J.Med. 318:663-670 (1988).
Bougneres et al., "Limited Duration of Remission of Insulin Dependency in Children with Recent Overt Type I Diabetes Treated with Low-Dose Cyclosporin", Diabetes 39:1264-1272 (1990).
Bregman et al., "Molecular Characterization of Bovine Brain P75, a High Affinity Binding Protein for the Regulatory Subunit of cAMP-dependent Protein Kinase II.beta.*", J.Biol.Chem. 266:7202-7213 (1991).
Bruton and Koeller, "Recombinant Interleukin-2", Pharmacotherapy 14:635-656 (1994).
Brynskov, "Cyclosporin in Crohn's disease", Dan.Med.Bull. 41:332-344 (1994).
Carr et al., "Follicle-stimulating Hormone Regulation of A-kinase Anchoring Proteins in Granulosa Cells*", J.Biol.Chem. 268:20729-20732 (1993).
Carr et al., "Association of the type II cAMP-dependent Protein Kinase with a Human Thyroid RII-anchoring Protein", J.Biol.Chem. 267:13376-13382 (1992).
Carr and Scott, "Blotting and band-shifting: techniques for studying protein-protein interactions", T.I.B.S. 17:246-249 (1992).
Carr et al., "Interaction of the Regulatory Subunit (RII) of cAMP-dependent Protein Kinase with RII-anchoring Proteins Occurs through an Amphipathic Helix Binding Motif*", J.Biol.Chem. 266:14188-14192 (1991).
Carr et al., "Localization of the cAMP-dependent Protein Kinase to the Postsynaptic Densities by A-Kinase Anchoring Proteins", J.Biol.Chem. 267:16816-16823 (1992).
Cheley et al., "Type II Regulatory Subunits of cAMP-dependent Protein Kinase and Their Binding Proteins in the Nervous System of Aplysia californica*", J.Biol.Chem. 269:2911-2920 (1994).
Choi and Targan, "Immunomodulator Therapy in Inflammatory Bowel Disease", Dig.Dis and Sci. 39:1885-1892 (1994).
Clipstone and Crabtree, "Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation", Nature 357:695-697 (1992).
Coghlan et al., "A-Kinase Anchoring Proteins: a key to selective activation of cAMP-responsive events?", Mol.Cell.Biochem. 127:309-319 (1993).
Coghlan et al., "Cloning and Characterization of AKAP 95, a Nuclear Protein That Associates with the Regulatory Subunit of Type II cAMP-dependent Protein Kinase*", J.Biol.Chem. 269:7658-7665 (1994).
Cooper et al., "Atopic Dermatitis: Recent Trends in Pathogenesis and Therapy", J.Invest.Derm 102:128-137 (1994).
Cuellar et al., "Treatment of psoriatic arthritis", Balliere's Clin.Rheum. 8:483-498 (1994).
Cyert and Thorner, "Calcineurin-like Activity in Saccharomyces cerevisiae", J.Cell.Biol. 107:841a (1989).
de Groen et al., "Central Nervous System Toxicity After Liver Transplantation", N.Eng.J.Med. 317:861-866 (1987).
DeCamilli et al., "Heterogeneous Distribution of the cAMP Receptor Protein RII in the Nervous System: Evidence for Its Intracellular Accumulation of Microtubules, Microtubule-organizing Centers, and in the Area of the Golgi Complex", J.Cell.Biol. 103:189-203 (1986).
Deeg et al., "Cyclosporine as Prophylaxis for Graft-Versus-Host Disease: A Randomized Study in Patients Undergoing Marrow Transplantation for Acute Nonlymphoblastic Leukemia", Blood 65:1325-1334 (1985).
Dillman, "The Clinical Experience with Interleukin-2 in Cancer Therapy", Cancer Biotherapy 9:183-209 (1994).
Dougados and Torley, "Efficacy of Cyclosproin A in Rheumatoid Arthritis: Worldwide Experience", Br.J.Rheum 32(suppl 1):57-59 (1993).
Durfee et al., "The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit", Genes and Development 7:555-567 (1993).
Eichholtz et al., "A Myristoylated Pseudosubstrate Peptide, a Novel Protein Kinase C Inhibitor*", J.Biol.Chem 268:1982-1986 (1993).
Eidelman et al., "Neurologic Complications of FK 506", Transplnt.Proc. 23:3175-3178 (1991).
Elliot and Chase, "Prevention or delay of Type 1 (insulin-dependent) diabetes mellitus in children using nicotinamide", Diabetologia 34:362-365 (1991).
Ellis et al., "Cyclosporine Improves Psoriasis in a Double-blind Study", JAMA 256:3110-3116 (1986).
Feldt-Rasmussen et al., "Oral cyclosporine for severe chronic idiopathic urticaria and angioedema", Diabetes Medicine 7:429-433 (1990).
Feutren, "Renal Morphology Afteer Cyclosporin A Therapy In Rheumatoid Arthritis Pateints," Br.J.Rheum. 32(suppl 1):65-71 (1993).
Feutren et al., "Cyclosporin Increases The Rate And Length Of Remissions In Insulin-Dependent Diabetes Of Recent Onset", Lancet 2:119-124 (1986).
F.o slashed.rre et al., "An Open, Controlled, Randomized Comparison Of Cyclosporine And Azathioprine In The Treatment Of Rheumatoid Arthritis: A Preliminary Report", Arthritis Reheum. 30:88-92 (1987).
Figlin et al., "Session II" AIDS/Cancer Therapies, Seminars in Hematology, 29(suppl 1):33-35 (1992).
Fradin et al., "Oral cyclosporine for severe chronic idiopathic urticaria and angioedema", J.Am.Acad.Derm. 25:1065-1067 (1991).
Fung et al., "Adverse Effects Associated With the Use of FK 506", Transplant.Proc. 23:3105-3108 (1991).
Glantz et al., "cAMP Signaling in Neurons: Patterns of Neuronal Expression and Intracellular Localization for a Novel Protein, AKAP 150, that Anchors the Regulatory Subunit of cAMP-Dependent Protein Kinase II.beta.", Mol.Cell.Biol. 3:1215-1228 (1992).
Glantz et al., "Characterization of Distinct Tethering and Intracellular Targeting Domains in AKAP75 a Protein That Links cAMP-dependent Protein Kinase II.beta. to the Cytoskeleton*", J.Biol.Chem. 268:12796-12804 (1993).
Greengard et al., "Enhancement of the Glutamate Response by cAMP-Dependent Protein Kinase in Hippocampal Neurons", Science 253:1135-1138 (1991).
Guerini and Klee, "Cloning of human calcineurin A: Evidence for two isozymes and identification of a polyproline structural domain", Proc.Natl.Acad.Sci.(USA) 86:9183-9187 (1989).
Harlow and Lane, "Immunoaffinity Purification of Antibodies on an Antigen Column", in Antibodies: A Laboratory Manual, Harlow and Lane (eds.) Cold Spring Harbor Laboratory:Cold Spring Harbor, NY (1988), pp. 313-318.
Hashimoto et al., "Identification of an Autoinhibitory Domain in Calcineurin*", J.Biol.Chem. 265:1924-1927 (1990).
Hathaway et al., "Interaction of Calmodulin with Myosin Light Chain Kinase and cAMP-dependent Protein Kinase in Bovine Brain*", J.Biol.Chem. 265:8183-8189 (1981).
Hausken et al., "Type II Regulatory Subunit (RII) of the cAMP-dependent Protein Kinase Interaction with A-kinase Anchor Proteins Requires Isoleucines 3 and 5*", J.Biol.Chem. 269:24245-24251 (1994).
Hirsch et al., "Cloning and Expression of an Intron-less Gene for AKAP 75, an Anchor Protein for the Regulatory Subunit of cAMP-dependent Protein Kinase II.beta.*", J.Biol.Chem. 267:2131-2134 (1992).
Hubbard and Cohen, "On target with a new mechanism for the reg
Kashishian Adam
Lockerbie Robert Owen
ICOS Corporation
Kemmerer Elizabeth C.
LandOfFree
Isolated polynucleotides encoding PKA-binding proteins and metho does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Isolated polynucleotides encoding PKA-binding proteins and metho, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Isolated polynucleotides encoding PKA-binding proteins and metho will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1113760