Isolated polynculeotides encoding T-cadherin adhesion molecule,

Details Isolated polynculeotides encoding T-cadherin adhesion molecule, Isolated polynculeotides encoding T-cadherin adhesion molecule,

1995-06-07

1998-11-17

Allen, Marianne P.

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

435361, 435 691, 4353201, 536 231, 536 235, 536 243, 536 2431, C07H 2104, C12N 121

Patent

active

058375252

ABSTRACT:
The invention provides substantially purified T-cadherin polypeptides and isolated nucleic acids which encode the T-cadherin polypeptides. Antibodies reactive with various forms of T-cadherin, but not reactive with N-, E- or P-cadherin are also provided. The invention provides methods for detecting the various forms of T-cadherin in a subject as well as a method of detecting tumor growth which consists of inhibiting the activity of T-cadherin in a tumor. A method of effecting traumatized neurons is provided. The method entails treating traumatized neurons with a therapeutically effective dose of T-cadherin.

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