Isolated perfused heart preparation and method of use

Chemistry: molecular biology and microbiology – Differentiated tissue or organ other than blood – per se – or... – Including perfusion; composition therefor

Reexamination Certificate

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C435S001100, C435S374000, C436S018000, C600S481000

Reexamination Certificate

active

07045279

ABSTRACT:
An isolated heart preparation in which essentially normal pumping activity of all four chambers of the heart is preserved, allowing for the use of the preparation in conjunction with investigations of electrode leads, catheters, cardiac implants and other medical devices intended to be used in or on a beating heart. The preparation may also be employed to investigate heart functions, in the presence or absence of such medical devices. In order to allow for visualization of heart structures and devices located within the chambers of the heart, a clear perfusate such as a modified Krebs buffer solution with oxygenation is circulated through all four chambers of the heart and the coronary vasculature. The preparation and recordings of the preparation may be used in conjunction with the design, development and evaluation of devices for use in or on the heart, as well as for use as an investigational and teaching aid to assist physicians and students in understanding the operation of the heart.

REFERENCES:
patent: 3607646 (1971-09-01), Roissart
patent: 5075210 (1991-12-01), Wikman-Coffelt
patent: 5716378 (1998-02-01), Minten
patent: 5807737 (1998-09-01), Schill et al.
patent: WO 91/14364 (1991-10-01), None
“Influence of Mitral Valve Prosthesis or Rigid Mitral Ring on Left Ventricular Pump Function” by van Rijk-Zwikker et al, Circulation vol. 80, Sep. 1989, Supplement 1, pp. 1-1-1-7.
“Mitral Valve Anatomy and Morphology: Relevance to Mitral Valve Replacement and Reconstruction” by van Rijk-Zwikker et al, Journal of Cardiac Surgery, 1994; 9 (Suppl) pp. 256-261.
“The Isolated Perfused Heart” by Langendorff et al, Biomesstechnik—Verlag, March GmbH, D-7806 March.

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