Isolated peptides which bind to HLA-C molecules and uses...

Details Isolated peptides which bind to HLA-C molecules and uses... Isolated peptides which bind to HLA-C molecules and uses...

2006-03-07

2006-03-07

Chan, Christina (Department: 1644)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

8 to 10 amino acid residues in defined sequence

Reexamination Certificate

active

07009035

ABSTRACT:
The invention teaches peptide epitopes which bind to HLA-Cw3 and HLA-Cw6 molecules on the surface of cells. The peptides are useful diagnostically and therapeutically, as are DNA molecules which encode them, and the cytolytic T lymphocytes specific to the HLA/peptide complexes. Also a feature of the invention is a method for identifying relevant molecules such as those described herein, in a system that uses stimulation and restimulation using different viral vectors.

REFERENCES:
Gnjatic, et al., “Strategy for monitoring T Cell Responses to NY-ESO-I In Patents With Any HLA Allele,” Proc. Natl. Acad. Sci. 97(20): 10917-10922 (Sep. 26, 2000, Not Prior Art).
Jäger, et al., “Induction of primary NY-ESO-I Immunity: CD8+ T lymphocyte and antibody responses in peptide vaccinated patients with NY-ESO-I+ Cancers,” Proc. Natl. Acad. Sci. 97 (22d: 12198-12203 (Oct. 24, 2000).

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