Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues
Patent
1995-06-07
2000-07-25
Scheiner, Laurie
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
530324, 530325, 530326, 530350, 4241861, 4242301, A61K 3800, A61K 3912, A61K 39245
Patent
active
060937947
ABSTRACT:
The present invention relates to peptides which exhibit potent anti-retroviral activity. The peptides of the invention comprise DP178 (SEQ ID:1) peptide corresponding to amino acids 638 to 673 of the HIV-1.sub.LAI gp41 protein, and fragments, analogs and homologs of DP178. The invention further relates to the uses of such peptides as inhibitory of human and non-human retroviral, especially HIV, transmission to uninfected cells.
REFERENCES:
patent: 4659669 (1987-04-01), Kleid et al.
patent: 4707358 (1987-11-01), Kieff et al.
patent: 5116725 (1992-05-01), Vaughan et al.
patent: 5141867 (1992-08-01), Ivanoff et al.
Wild C. et al., A synthetic peptide inhibitor of human immunodeficiency virus replication: Correlation between solution structure and viral inhibition, Proc. Nat'l. Acad. Sci. USA 89:10537-10541, Nov. 1992.
Baer R. et al., DNA sequence and expression of the B95-8 Epstein-Barr virus genome, Nature 310:207-211, Jul. 1984.
Beisel et al., 1985, "Two Major Outer Envelope Glycoproteins of Epstein-Barr Virus Are Encoded by the Same Gene", J. Virol. 54(3):665-674.
Mackett et al., 1990, "Characterization and Expression of a Glycoprotein Encoded by the Epstein-Barr Virus BamHI I Fragment", J. Virol. 64(6):2545-2552.
Guyader et al., 1987, "Genome organization and transactivation of the human immnodeficiency virus type 2", Nature 326:662-669.
Clavel et al., 1986, "Isolation of a new human retrovirus from west african patients with AIDS", Science 233:343-346.
Klatzmann et al., 1984, "T-lymphocyte T4 molecule behaves as the receptor for human retrovirus LAV", Nature 312:767-768.
Teich et al., 1984, Pathogenesis of lentivirus, in "RNA Tumor Viruses", Weiss et al., eds., CSH-Press, pp. 949-956.
Barre-Sinoussi et al., 1983, "Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS)", Science 220:868-870.
Carr and Kim, 1993, "Aspring loaded mechanism for the conformational change of influenza hemagglutinin", Cell 73:823-832.
Songyang et al., 1993, "SH2 domains recognize specific phosphopeptide sequences", Cell 72:767-778.
Lam et al., 1991, "The new type of synthetic peptide library for identifying ligand-binding activity", Nature 354-82-84.
Lupas et al., "Predicting coiled coils from protein sequences", Science 252:1162-1165.
Xu et al., 1991, "Epitope mapping of two immunodominant domains of gp41, the transmembrane protein of human immunodeficiency virus type 1, using ten human monoclonal antibodies", J. Virology 65:4832-4838.
Chambers et al, 1990, "Heptad repeat sequences are located adjacent to hydrophobic regions in several types of virus fusion glycoproteins", J. Gen. Virology 71:3075-3080.
Malim et al., 1988, "Immunodeficiency virus rev trans-activator modulates the expression of the viral regulatory genes", Nature 355-181-183.
Suzuki et al., 1995, "Viral Interlukin10 (IL-10), the Human Herpes Virus 4 Cellular IL-10 Homologue, Induces Local Anergy to Allogenic and Syngeneic Tumors", J. of Experimental Medicine 182:477-486.
Wild et al., 1984, "Propensity for a Leucine Zipper-Like Domain of Human Immunodeficiency Virus Type 1 gp41 to Form Oligomers Correlates With a Role in Virus-Induced Fusion Rather Than Assembly of the Glycoprotein Complex", Proc. Natl. Acad. Sci. USA 91:12676-80.
Bousse et al., 1994, "Regions on the Hemagglutinin-Neuraminidase Proteins of Human Parainfluenza Virus Type-1 and Sendai Virus Important for Membrane Fusion", Virology 204:506-514.
Wang et al., 1993, "Ion Channel Activity of Influenza A Virus M2 Protein: Characterization of the Amantidine Block", J of Virology 67:5585-94.
Daar et al., 1990, "High concentrations of recombinant soluble CD4 are required to neutralize primary human immunodeficiency virus type 1 isolates", Proc. Natl. Acad. Sci. USA 87:6574-6579.
Smith et al., 1987, "Blocking of HIV-1 Infectivity by a Soluble, Secreted Form of the CD4 Antigen", Science 238:1704-1707.
Collins et al., 1984, "Nucleotide Sequence of the Gene Encoding the Fusion (F) Clycoprotein of Human Respiratory Syncytial Virus", Proc. Natl. Acad. Sci. USA 81:7683-87.
Gallaher et al., 1989, "A General Model for the Transmembrane Proteins of HIV and Other Retroviruses", AIDS Res. and Human Retgroviruses 5:431-440.
Jiang et al., 1993, "Inhibition of HIV-1 Infection by a Fusion Domain Binding Peptide from the HIV-1 Envelope Glycoprotein gp41", Biochem. Biophy. Res. Comm. 195:533-538.
Kingsbury, 1990, "Paramyxoviridae and Their Replication", In Virology, 2.sup.nd Edition, Fields et al., eds., Raven Press, New York, p. 951.
Okamoto et al., 1988, "Typing Hepatitis B Virus by Homology in Nucleotide Sequence: Comparison of Surface Antigen Subtypes", J. Gen. Virol. 69:2575-2583.
Richardson et al., 1986, "The Nucleotide Sequence of the mRNA Encoding the Fusion Protein of Measles Virus (Edmonston Strain): A Comparison of Fusion Proteins from Several Different Paramyxoviruses", Virol. 155:508-523.
Staden, 1994, "Searching for Motifs in Protein Sequences", Chapter 12 in : Methods in Molecule Biology, vol. 25, Griffin et al., eds., Humana Press, Inc., Totowa, NJ, pp. 131-139.
Staden, 1994, "Using Patterns to Analyze Protein Sequences", Chapter 13 in: Methods in Molecule Biology, vol. 25, Griffin et al., eds., Humana Press, Inc., Totowa, NJ, pp. 141-154.
Staden, 1990, "Searching for Patterns in Protein and Nucleic Acid Sequences", Meth. Enzymol. 183:193-211.
Tyler et al., 1990, "Identification of Sites Within gp41 That Serve as Targets for Antibody-Dependent Cellular Cytotoxicity by Using Human Monoclonal Antibodies", J. Immunol. 145:3276-3282.
Wild et al., 1994, "Peptides Corresponding to a Predictive .alpha.-Helical Domain of Human Immunodeficiency Virus Type 1 gp41 Are Potent Inhibitors of Virus Infection", Proc. Natl. Acad. Sci. USA 91:9770-9774.
Wild et al., 1993, "A Synthetic Peptide from HIV-1 gp41 is a Potent Inhibitor of Virus-Mediated Cell-Cell Fusion", AIDS Res. And Human Retroviruses 9:1051-1053.
Barney Shawn O'Lin
Lambert Dennis Michael
Petteway Stephen Robert
Parkin Jeffrey S.
Scheiner Laurie
Trimeris, Inc.
LandOfFree
Isolated peptides derived from the Epstein-Barr virus containing does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Isolated peptides derived from the Epstein-Barr virus containing, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Isolated peptides derived from the Epstein-Barr virus containing will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1337326