Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1991-03-28
1992-12-08
Cashion, Jr., Merrell C.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
530350, 530840, 424549, A61K 3700, C07K 300
Patent
active
051698374
ABSTRACT:
Described is a purified osteogenic factor that when delivered to bone in association with a physiologically acceptable delivery vehicle is capable of inducing new bone growth at the bone surface. The osteogenic factor is water soluble, and is characterized physically by a molecular weight of about 2.5 kD when measured by gel filtration under dissociating conditions and an isoelectric point in the pH range from about 4.6 to 7.2. Use of the purified factor in treating bone defects is described. Also described is a method for obtaining the purified factor from mammalian bone.
REFERENCES:
patent: 3458397 (1969-07-01), Myers, et al.
patent: 4774322 (1988-09-01), Seyedin et al.
patent: 4795804 (1989-01-01), Urist
Clark et al., Clin. Ortho. Rel. Res. vol. 237 226-235 (1988).
David N. Tornberg, et al.; (Nov.-Dec., 1977); Clinical Orthopaedics and Related Research; vol. 129; pp. 305-312; "Activation of the Resting Periosteum".
Irwin Clark, et al.; (Dec., 1988); Clinical Orthopaedics and Related Research; vol. 237; pp. 226-235; "Bone-Cell-Stimulating Substance".
Abdulwajid Abdulwahid
Bueschkens Donna
Byrne Deanna
Lagarde Alain E.
Allelix Biopharmaceuticals Inc.
Cashion Jr. Merrell C.
Celsa B.
Glaxo Canada Inc.
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