Isolated nucleotide sequences encoding an: antigen binding site

Details Isolated nucleotide sequences encoding an: antigen binding site Isolated nucleotide sequences encoding an: antigen binding site

1993-07-13

1994-05-24

Lacey, David L.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

435 7021, 4351722, 43524027, 5303871, 53038815, 53038822, 5303888, 530350, 530395, 536 2353, 536 235, A61K 3516, C07K 1528, C07K 1300, C07H 1700

Patent

active

053149963

ABSTRACT:
Monoclonal antibodies that bind specifically to prostate carcinoma and do not bind substantially to normal prostate or benign prostatic hyperplasia, as well as hybridoma cell lines producing the monoclonal antibodies are disclosed. In one embodiment, a monoclonal antibody designated MAb PD41 is disclosed. A new antigen designated prostate mucin antigen is disclosed in isolated, substantially pure form. In addition, methods for using the hybridoma cell lines, the monoclonal antibody and/or the antigen for diagnosis, prophylaxis and/or treatment of prostate carcinoma are disclosed.

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