Isolated nucleic acids, vectors and host cells encoding...

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

Reexamination Certificate

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C435S091100, C435S325000

Reexamination Certificate

active

09825584

ABSTRACT:
Antibodies are disclosed which bind to ErbB3 protein and further possess any one or more of the following properties: an ability to reduce heregulin-induced formation of an ErbB2-ErbB3 protein complex in a cell which expresses ErbB2 and ErbB3; the ability to increase the binding affinity of heregulin for ErbB3 protein; and the characteristic of reducing heregulin-induced ErbB2 activation in a cell which expresses ErbB2 and ErbB3.

REFERENCES:
patent: 4816397 (1989-03-01), Boss et al.
patent: 4816567 (1989-03-01), Cabilly et al.
patent: 4975278 (1990-12-01), Senter et al.
patent: 5183884 (1993-02-01), Kraus et al.
patent: 5258498 (1993-11-01), Huston et al.
patent: 5480968 (1996-01-01), Kraus et al.
patent: 5618920 (1997-04-01), Robinson et al.
patent: 5783186 (1998-07-01), Arakawa et al.
patent: 5783404 (1998-07-01), Koski
patent: 5820859 (1998-10-01), Kraus et al.
patent: 5916755 (1999-06-01), Kraus et al.
patent: 5968511 (1999-10-01), Akita et al.
patent: 444961 (1991-09-01), None
patent: 502812 (1992-09-01), None
patent: 0599274 (1994-06-01), None
patent: WO91/08214 (1991-06-01), None
patent: WO92/20798 (1992-11-01), None
patent: WO93/16185 (1993-08-01), None
patent: WO93/21319 (1993-10-01), None
patent: WO94/04679 (1994-03-01), None
patent: WO94/08007 (1994-04-01), None
patent: WO94/22478 (1994-10-01), None
patent: WO95/14776 (1995-06-01), None
patent: WO97/20858 (1997-06-01), None
Orlandi et al (Proc. Natl. Acad. Sci. USA, 86:3833-3837, 1989).
Ward et al (Nature 341:544-546, 1989).
Queen et al (PNAS 1989;86:10029-33).
Greenspan et al. (Nature Biotechnology 7: 936-937, 1999).
Kraus et al., “Isolation and characterization of ERBB3, a third member of the ERBB/epidermal growth factor receptor family: Evidence for overexpression in a subset of human mammary tumors”Proc. Natl. Acad. Sci. USA86:9193-9197 (Dec. 1989).
Lee et al., “Assignment of heregulin (HGL) to human chromosome 8p22-p11 by PCR analysis of somatic cell hybrid DNA”Genomics16:790-791 (1993).
Lemoine et al., “Expression of the ERBB3 gene product in breast cancer”Br. J. Cancer66:1116-1121 (1992).
Lemoine et al., “The erbB-3 gene in human pancreatic cancer”J. Pathol. 168:269-273 (1992).
Levi et al., “The Influence of Heregulins on Human Schwann Cell Proliferation”J. Neuroscience15(2):1329-1340 (Feb. 1995).
Lewis et al., “Growth Regulation of Human Breast and Ovarian Tumor Cells by Heregulin: Evidence for the Requirement of ErbB2 as a Critical Component in Mediating Heregulin Responsiveness”Cancer Research56:1457-1465 (Mar. 15, 1986).
Marchionni et al., “Glial growth factors are alternatively spliced erbB2 ligands expressed in the nervous system”Nature362:312-318 (1993).
Morrissey et al., “Axon-induced mitogenesis of human Schwann cells involves heregulin and p185erbB2”Proc. Natl. Acad. Sci. USA92:1431-1435 (Feb. 1995).
Orr-Urtreger et al., “Neural expression and chromosomal mapping of Neu differentiation factor to 8p12-p21”Proc. Natl. Acad. Sci. USA90:1867-1871 (1993).
Peles et al., “Isolation of the Neu/HER-2 Stimulatory Ligand: A 44 Kd Glycoprotein That Induces Differentiation of Mammary Tumor Cells”Cell69(1) :205-216 (1992).
Plowman et al., “Heregulin induces tyrosine phosphorylation of HER4/p180erbB4”Nature(Letters to Nature) 366:473-475 (Dec. 2, 1993).
Plowman et al., “Ligand-specific activation of HER4/p180erbB4, a fourth member of the epidermal growth factor receptor family”Proc. Natl. Acad. Sci. USA90:1746-1750 (Mar. 1993).
Plowman et al., “Molecular cloning and expression of an additional epidermal growth factor receptor-related gene”Proc. Natl. Acad. Sci. 87:4905-4909 (1990).
Poller et al., “Production and characterization of a polyclonal antibody to the c-erbB-3 protein: examination of c-erbB-3 protein expression in adenocarcinomas”J. Pathol. 168(3):275-280 (1992).
Rajkumar et al., “A monoclonal antibody to the human c-erbB3 protein stimulates the anchorage-independent growth of breast cancer cell lines”Br. J. Cancer70(3):459-465 (1994).
Rajkumar et al., “Expression of the c-erbB-3 protein in gastrointestinal tract tumours determined by monoclonal antibody RTJ1”J. Pathol. (Published erratum appears in J.Pathol.1993 Oct.;171(2):154) 170:271-278 (1993).
Ram et al., “Mitogenic Activity of Neu Differentiation Factor/Heregulin Mimics That of Epidermal Growth Factor and Insulin-Like Growth Factor-1 in Human Mammary Epithelial Cells”J. Cellular Physiology163:589-596 (1995).
Sanidas et al., “Expression of the c-erbB-3 gene product in gastric cancer”Int. J. Cancer54:935-940 (1993).
Slamon et al., “Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2
eu Oncogene”Science235:177-182 (Jan. 9, 1987).
Slamon et al., “Studies of the HER-2
eu Proto-oncogene in Human Breast and Ovarian Cancer”Science244:707-712 (May 12, 1989).
Bacus et al., “Expression of the erbB-2 Family of Growth Factor Receptors and Their Ligands in Breast Cancers”Pathology Patterns(Suppl. 1) 102(4) :S13-S24 (1994).
Falls et al., “ARIA, a protein that stimulates acetylcholine receptor synthesis, is a member of the Neu ligand family”Cell72:801-815 (1993).
Fendly et al., “Characterization of Murine Monoclonal Antibodies Reactive to Either the Human Epidermal Growth Factor Receptor or HER2
eu Gene Product”Cancer Research50:1550-1558 (Mar. 1, 1990).
Friess et al., “Enhanced erbB-3 Expression in Human Pancreatic Cancer Correlates with Tumor Progression”Clinical Cancer Research1:1413-1420 (1995).
Griffiths et al., “Human Anti-Self Antibodies With High Specific From Phage Display Libraries”EMBO Journal12(2):725-734 (1993).
Guy et al., “Insect Cell-expressed p180erbB3Possesses an Impaired Tyrosine Kinase Activity”Proc. Natl. Acad. Sci. USA91:8132-8136 (Aug. 1994).
Holmes et al., “Identification of Heregulin, a Specific Activator of p185erbB2”Science256:1205-1210 (May 22, 1992).
Kim et al., “Epidermal growth factor-dependent association of phosphatidylinositol 3-kinase with the erbB3 gene product”Journal of Biological Chemistry269(40):24747-24755 (1994).
Kraus et al., “Demonstration of ligand-dependent signaling by the erbB-3 tyrosine kinase and its constitutive activation in human breast tumor cells”Proc. Natl. Acad. Sci. 90:2900-2904 (1993).
Sliwkowski et al., “Coexpression of erbB2 and erbB3 Proteins Reconstitutes a High Affinity Receptor for Heregulin”Journal of Biological Chemistry269(20):14661-14665 (May 20, 1994).
Wallasch et al., “Heregulin-dependent regulation of HER2
eu oncogenic signaling by heterodimerization with HER3”EMBO Journal14(17):4267-4275 (1995).
Wen et al., “Neu differentiation factor: a transmembrane glycoprotein containing an EGF Domain and an Immunoglobulin Homology Unit”Cell69(3):559-572 (1992).
Wen et al., “Structural and functional aspects of the multiplicity of neu differentiation factors”Molecular&Cellular Biology14(3):1909-1919 (1994).

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