Isolated nucleic acids encoding methylenetetrahydrofolate...

Details Isolated nucleic acids encoding methylenetetrahydrofolate... Isolated nucleic acids encoding methylenetetrahydrofolate...

2005-01-04

2005-01-04

Prouty, Rebecca E. (Department: 1652)

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

C435S026000, C435S320100, C435S190000, C435S325000, C435S069100, C435S191000, C536S023200, C530S350000

Reexamination Certificate

active

06838276

ABSTRACT:
This invention relates to an isolated nucleic acid fragment encoding a tetrahydrofolate metabolism enzyme. The invention also relates to the construction of a chimeric gene encoding all or a portion of the tetrahydrofolate metabolism enzyme, in sense or antisense orientation, wherein expression of the chimeric gene results in production of altered levels of the tetrahydrofolate metabolism enzyme in a transformed host cell.

REFERENCES:
Nguyen et al., SPTREMBL accession No. O65271, Aug. 1, 1998.*
Mary G. West et al., Cloning and Characterization of the Saccharomyces cerevisiae Gene Encoding NAD-dependent 5,10-Methylenetetrahydrofolate Dehydrogenase, J. Biol. Chem., vol. 268(1):153-160. 1993.
Linda D'Ari et al., Purification, Characterization, Cloning, and Amino Acid Sequence of the Bifunctional Enzyme 5,10-Methylenetetrahydrofolate Dehydrogenase/5,10-Methenyltetrahydrofolate Cyclohydrolase fromEscherichia coli,J. Biol. Chem., vol. 266(35):23953-23958, 1991.
Warren Gish et al., Identification of protein coding regions by database similarity search, Nature Genetics, vol. 3:266-272, 1993.
National Center for Biotechnology Information General Identifier No. 5001995, Accession No. AAD37248, Jun. 7, 1999, D. Kurtov et al., TheAspergillus nidulanspanB gene encoding eukaryotic ketopanloate hydroxymethyltransferase required for pantothenate and coenzyme A biosynthesis.
National Center for Biotechnology Information General Identifier No. 2984098, Accession No: AAC07636, Mar. 25, 1998, G. Deckert et al., The complete genome of the hyperthermophilic bacteriumAquifex aeolicus.
Gerard Deckert et al., The complete genome of the hyperthermophilic bacteriumAquifex aeolicus,Nature, vol. 392:353-358, 1998.
National Center for Biotechnology Information General Identifier No. 2500006, Accession No: Q46339, Jul. 15, 1999, L.J. Chlumsky et al., Sequence analysis of sarcosine oxidase and nearby genes reveals homologies with key enzymes of folate one-carbon metabolism.
Lawrence J. Chlumsky et al., Sequence analysis of sarcosine oxidase and nearby genes reveals homologies with key enzymes of folate one-carbon metabolism, J. Biol. Chem., vol. 270(31):18252-18259, 1995.
National Center for Biotechnology Information General Identifier No. 1706872, Accession No: P53603, Feb. 15, 2000, L. L. Murley et al., The nucleotide sequence of porcine formiminotransferase cyclodeaminase. Expression and purification fromEscherichia coli.
Laura Lea Murley et al., The nucleotide sequence of porcine formiminotransferase cyclodeaminase. Expression and purification fromEscherichia coli,J. Biol. Chem., vol. 268(30):22820-22824, 1993.
National Center for Biotechnology Information General Identifier No. 4103987, Accession No: AAD01907, Jan. 5, 1999, L. Chen et al., A cDNA sequence encoding pea leaf cytosolic bifunctional dehydrogenase-5,10-methenyltetrahydrofolate cyclohydrolase.
National Center for Biotechnology Information General Identifier No. 1685109, Accession No: U58210, Nov. 28, 1996, F. Stingele et al., Disruption of the gene encoding penicillin-binding protein 2b (pbp2b) causes altered cell morphology and cease in exopolysaccharide production inStreptococcus thermophilusSfi6.
Francesca Stingele et al., Disruption of the gene encoding penicillin-binding protein 2b (pbp2b) causes altered cell morphology and cease in exopolysaccharide production inStreptococcus thermophilusSfi6, Mol. Microbiology, vol. 22(2):357-366, 1996.
Peter L. Nagy et al., Formyltetrahydrofolate Hydrolase, a Regulatory Enzyme That Functions to Balance Pools of Tetrahydrofolate and One-Carbon Tetrahydrofolate Adducts inEscherichia coli,J. Bacteriology, vol. 177(5):1292-1298, 1995.
Karen W. Shannon et al., Isolation and Characterization of theSaccharomyces cerevisiaeMIS1 Gene Encoding Mitochondrial C1-Tetrahydrofolate Synthase, J. Biol. Chem., vol. 263(16):7717-7725, 1988.
National Center for Biotechnology Information General Identifier No. 2245073, Accession No. Z97343, Aug. 27, 1999, M. Bevan et al.,Arabidopsis thalianaDNA chromosome 4, ESSA I FCA contig fragment No. 8.
Marc Allaire et al., The 3-D structure of a folate-dependent dehydrogenase/cyclohydrolase bifunctional enzyme at 1.5 A resolution, Structure 6(2):173-182, 1998.
Swiss Institute of Bioinformatics Prosite Accession No. PDOC00616, Jul. 1998, K. W. Shannon et al., Isolation and Characterization of theSaccharomyces cerevisiaeMIS1 Gene Encoding Mitochondrial C1-Tetrahydrofolate Synthase.

Affiliated with

Also associated with

Rating

Isolated nucleic acids encoding methylenetetrahydrofolate... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Isolated nucleic acids encoding methylenetetrahydrofolate..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Isolated nucleic acids encoding methylenetetrahydrofolate... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3423860