Isolated nucleic acids encoding glutamate receptor protein

Details Isolated nucleic acids encoding glutamate receptor protein Isolated nucleic acids encoding glutamate receptor protein

1991-06-21

1993-04-13

Hill, Jr., Robert J.

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

435 691, 4353201, 536 243, 536 231, C12N 1512, C12N 1563

Patent

active

052022579

ABSTRACT:
The present invention discloses novel DNAs that encode proteins having electrophysiological and pharmacological properties characteristic of glutamate receptors. The glutamate receptors are exemplified by proteins encoded by representative cDNA clones GluR1, GluR2, GluR3, GluR4, GluR5, GluR6 and GluR7, fragments thereof, and functional combinations of these glutamate receptor proteins and/or fragments. DNA sequences from the cDNA clones for GluR1, GluR2, GluR3, GluR5 and GluR5 are especially useful as probes, thus enabling those skilled in the art to identify, without undue experimentation, other members of the L-glutamate receptor family.

REFERENCES:
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Wada et al, Sequence and expression of a frog brain complementary DNA encoding a kainate-binding protein, Nature vol. 342:684-689 (1989).
Gregor et al., Molecular structure of the chick cerebellar kainate-binding subunit of a putative glutamate receptor, Nature vol. 342:689-692 (1989).
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Masu et al., "Sequence and expression of a metabotropic glutamate receptor", Nature vol. 349:760-765 (1991).

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