Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of...
Reexamination Certificate
2006-11-28
2006-11-28
Saoud, Christine J. (Department: 1647)
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
C435S252300, C435S320100, C435S069100, C536S023500
Reexamination Certificate
active
07141419
ABSTRACT:
The invention provides isolated nucleic acid and amino acid sequences of CNG3B, antibodies to CNG3B, methods of detecting CNG3B, and methods of screening for modulators of cyclic nucleotide-gated ion channels using biologically active CNG3B. The invention further provides, in a computer system, a method of screening for mutations of human CNG3B genes as well as a method for identifying a three-dimensional structure of human CNG3B polypeptides.
REFERENCES:
Bork. (2000). Power and pitfalls in sequence analysis: the 70% hurdle. Genome Research 10:398-400.
Finn et al. (1996). Cyclic nucleotide-gated eion channels: an extended family with diverse functions. Ann. Rev. of Physiol. 58:395-426.
Ngo et al. (1990). Computational complexity, protein structure prediction, and the Levinthal paradox. In Merz and Le Grand (Eds.) The Protein Folding Problem and Tertiary Structure Prediction. Birkhauser:Boston.
Wells, J.A. (1990). Addivity of mutational effects in proteins. Biochemistry 29:8509-8517.
Skolnick et al. (2000). From genes to protein structure and function: novel applications of computational approaches in the genomic era. Trends in Biotech. 18:34-39.
Kramer et al. (2001). Modulation of cyclic-nucleotide-gated channels and regulation of vertebrate phototransduction. The Journal of Experimental Biology. 204:2921-2931.
Peng et al. (2003). Achromatopsia-associated mutation in the human cone photoreceptor cyclic nucleotide-gated channel CNG3B subunit alters the ligand sensitivity and pore properties of heteromeric channels. J. Biol. Chem. 278(36):34533-34540.
Broillet et al. (1999). Cyclic nucleotide-gated channels. Molecular mechanisms of activation. Annals New York Academy of Sciences. 868:730-40.
Gerstner, et al., “Molecular Cloning and Functional Characterization of a New Modulatory Cyclic Nucleotide-Gated Channel Subunit from Mouse Retina”;The Journal of Neuroscience, 20(4):1324-1332 (Feb. 2000).
Kohl, et al., “Mutations in the CNGB3 gene encoding the β-subunit of the cone photoreceptor cGMP-gated channel are responsible for achromatopsia (ACHM3) linked to chromosome 8q21”;Human Molecular Genetics,vol. 9, No. 14 2107-2116 (2000).
Sundin, et al. “Genetic basis of total colourblindness among the Pingelapese islanders”;Nature Genetics,vol. 25, 289-293 (Jul. 2000).
Vinós, et al., “A G Protein-Coupled Receptor Phosphatase Required for Rhodopsin Function”Sciencevol. 277, 687-690 (Aug. 1997).
Gerstner, Andrea et al.; “Molecular Cloning and Functional Characterization of a New Modulatory Cyclic Nucleotide-Gated Channel Subunit from Mouse Retina”; 2000,The Journal of Neuroscience,vol. 20, No. 4, pp. 1324-1332.
Database EMBL, Jul. 6, 2000, retrived from EMBL Database accession No. AF228520.
Creech Christopher D.
Jegla Timothy J.
Icagen Inc.
Lockard Jon M
Saoud Christine J.
Townsend and Townsend / and Crew LLP
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