Isolated nucleic acids encoding cyclic nucleotide-gated...

Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of...

Reexamination Certificate

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C435S252300, C435S320100, C435S069100, C536S023500

Reexamination Certificate

active

07141419

ABSTRACT:
The invention provides isolated nucleic acid and amino acid sequences of CNG3B, antibodies to CNG3B, methods of detecting CNG3B, and methods of screening for modulators of cyclic nucleotide-gated ion channels using biologically active CNG3B. The invention further provides, in a computer system, a method of screening for mutations of human CNG3B genes as well as a method for identifying a three-dimensional structure of human CNG3B polypeptides.

REFERENCES:
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Gerstner, et al., “Molecular Cloning and Functional Characterization of a New Modulatory Cyclic Nucleotide-Gated Channel Subunit from Mouse Retina”;The Journal of Neuroscience, 20(4):1324-1332 (Feb. 2000).
Kohl, et al., “Mutations in the CNGB3 gene encoding the β-subunit of the cone photoreceptor cGMP-gated channel are responsible for achromatopsia (ACHM3) linked to chromosome 8q21”;Human Molecular Genetics,vol. 9, No. 14 2107-2116 (2000).
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Database EMBL, Jul. 6, 2000, retrived from EMBL Database accession No. AF228520.

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