Chemistry: molecular biology and microbiology – Spore forming or isolating process
Patent
1993-03-18
1997-04-15
Wax, Robert A.
Chemistry: molecular biology and microbiology
Spore forming or isolating process
435 723, 435 29, 4352523, 4353201, 435 691, 514 44, 536 221, 536 231, 536 235, 530350, C12N 500, C12P 2100, C07H 1900, C07K 100
Patent
active
056208863
ABSTRACT:
The invention relates to nucleic acid molecules coding for a tumor rejection antigen precursor. Specifically, the tumor rejection antigen precursor, or "TRAP", is processed into at least one tumor rejection antigen, which is presented by HLA-A2 molecules. Ramifications of the discovery are also set forth.
REFERENCES:
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Traversari et al., "A Nonapeptide Encoded by Human Gene MAGE-1 is Recognized on HLA-A1 by Cytolytic T Lymphocytes Directed Against Tumor Antigen Mz2-E", J. Exp. Med. 176: 1453-1457 (Nov. 1992).
Van der Bruggen et al., "A Gene Encoding an Antigen Recognized by Cytolytic T Lymphocytes on a Human Melanoma", Science 254: 1643-1647 (Dec. 13, 1991).
Van den Eynde et al., "Presence on a Human Melanoma of Multiple Antigens Recognized by Autologous CTL", Int. J. Cancer 44: 634-640 (1989).
Bodmer et al., "Anti-HLA-A2 antibody-enhancement of peptide association with HLA-A2 as detected by cytotoxic T Lymphocytes", Nature 342: 443-446.
Wolfel et al., "Lysis of Human Melanoma Cells by Autologous Cytolytic T Cell Clones", J. Exp. Med. 170: 797-810 (Sep. 1989).
Darrow et al., "The Role of HLA Class 1 Antigens in Recognition of Melanoma Cells by Tumor-Specific Cytotoxic T Lymphocytes", J. Immunol. 142(9): 3329-3335 (May 1, 1989).
Knuth et al., "Cytolytic T-cell clones against an autologous human melanoma: specificity study and definition of three antigens by immunoselection", Proc. Natl., Acad., Sci USA 86: 2804-2808 (Apr. 1989.
Glover "Expression of cloned genes in animal cells." Gene cloning, pp. 179-217 1984.
Boon-Falleur Thierry
Brichard Vincent
De Plaen Etienne
Pel Aline Van
Traversari Catia
Kim Hyosuk
Ludwig Institute for Cancer Research
Wax Robert A.
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