Chemistry: molecular biology and microbiology – Process of mutation – cell fusion – or genetic modification – Introduction of a polynucleotide molecule into or...
Patent
1997-07-24
2000-02-01
Stanton, Brian R.
Chemistry: molecular biology and microbiology
Process of mutation, cell fusion, or genetic modification
Introduction of a polynucleotide molecule into or...
435440, 514 44, C12N 1500
Patent
active
060202017
ABSTRACT:
A protein having polysialyl transferase activity, which a) is a product of a prokaryotic or eukaryotic expression of an exogenous DNA, b) is coded by the DNA sequence shown in SEQ ID No. 1, c) is coded by the DNA sequences which hybridize with the sequences SEQ ID No. 1 and/or SEQ ID No. 3, d) is coded by DNA sequences which if there was no degeneracy of the genetic code, would hybridize with the sequences defined in b) to c), and e) catalyzes the polycondensation of .alpha.-2,8-linked sialic acids, and its related nucleic acid molecules and fragments are useful for the production of therapeutic agents for tumor therapy.
REFERENCES:
Friedmann, T. Gene therapy for Neurological Disorders. TIG, vol. 10, No. 6, pp. 210-214, Jun. 1994.
Yamamoto et al. Alpha 2,6-Sialyltransferase Gene Transfectin into a Human Glioma Cell Line (U373 MG) Resuslts in Decreased Invasivity. J. of Neurochem., vol. 68, No. 6, pp. 2566-2576, 1997.
Eckhardt et al. Molecular Characterization of Eukaryotic Polysialytrasnferase-1. Nature, vol. 373, pp. 715-718, Feb. 23, 1995.
Orkin et al. Report and Recommendations of the Panel to Assess the NIH Investment in Research on Gene Therapy. Distributed by the National Institutes of Health, Bethesda, MD. www.nih.gov. Dec. 7, 1995.
Eckhardt Matthias
Fukuda Minoru
Gerardy-Schahn Rita
Nakayama Jun
Boehringer Mannheim GmbH
Clark Deborah J. R.
Stanton Brian R.
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