Isolated nucleic acid molecules useful as leukemia markers and i

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

536 2431, 536 231, 536 235, 530300, 530350, 4353201, 435325, 4352523, 43525411, C12N 1511, C12N 1509, C12N 510, C07K 14705

Patent

active

059812184

ABSTRACT:
The present invention relates to four novel human genes amplified and overexpressed in breast carcinoma and located on the q11-q21.3 region of chromosome 17. The four novel genes are useful in breast cancer prognosis. The present invention also relates to a fifth novel human gene expressed in breast carcinoma and located on chromosome 6q22-q23. A sixth novel gene is also described that is the murine homolog of the human D52 gene. The genes and gene fragments of the present invention are themselves useful as DNA and RNA probes for gene mapping by in situ hybridization with chromosomes and for detecting gene expression in human tissues (including breast and lymph node tissues) by Northern blot analysis.

REFERENCES:
patent: 5556956 (1996-09-01), Roy et al.
patent: 5618717 (1997-04-01), Wei et al.
Pearson et al., Improved tools for biological sequence comparison, Proc. Natl. Acad. Sci. USA, 85: 2444-2448, Apr. 1988.
Adams, M.D. et al., "Sequence identification of 2,375 human brain genes," Nature 355:632-634 (1992).
Adams, M.D. et al., "Rapid cDNA sequencing (expressed sequence tags) from a directionally cloned human infant brain cDNA library," Nat. Genet. 4(4):373-380 (1993).
Basset, P. et al., "A novel metalloproteinase gene specifically expressed in stromal cells of breast carninomas," Nature 348:699-704 (1990).
Borg, A. et al., "ERBB2 amplification in breast cancer with a high rate of proliferation," Oncogene 6:137-143 (1991).
Byrne, J.A. et al., "A Screening Method to Identify Genes Commonly Overexpressed in Carcinomas and the Identification of a Novel Complementary DNA Sequence," Cancer Res. 55:(13):2896-2903 (Jul. 1995).
Contesso, G. et al., "Tumor Grade as a Prognostic Factor in Primary Breast Cancer," Eur. J. Clin. Oncol. 25(3):403-409 (1989).
Dang, C.V. & Lee, W.M.F., "Nuclear and Nucleolar Targeting Seuqences of c-erb-A, c-myb, N-myc, p53, HSP70, and HIV tat Proteins," J. Biol. Chem. 264(30):18019-18023 (1989).
Dingwall, C. & Laskey, R.A., "Nuclear targeting seuqnces--a consensus?" TIBS 16:478-481 (1991).
Dougall, W.C. et al., "The neu-onocogene: signal transduction pathways, transformation mechanisms and evolving therapies," Oncogene 9(8):2109-2123 (1994).
Driscoll, D.M. & Williams, J.G., "Two Divergently Transcribed Genes of Dictyostelium discoideum Are Cyclic AMP-Inducible and Coregulated during Development," Mol. Cell. Biol. 7(12):4482-4489 (1987).
Elias, J.M. et al., "Paraffin Embedded Breast Carcinomas for the Immunohistochemical Study of Prognostic Factors," J. Histotechnol. 15(4):315-320 (1992).
Fidler, I.J. & Ellis, L.M., "The Implications of Angiogenesis for the Biology and Therapy of Cancer Metastasis," Cell 79(2):185-188 (1994).
Freemont, P.S., "The RING Finger: A Novel Protein Sequence Motif Related to the Zinc Finger," Ann. N.Y. Acad. Sci. 684:174-192 (1993).
Fukushige, S.-I. et al., "Localization of a Novel-v-erbB-Related Gene, c-erbB-2, on Human Chromosome 17 and Its Amplification in a Gastric Cancer Cell Line," Mol. Cell. Biol. 6(3):955-958 (1986).
Futreal, P.A. et al., "BRCA1 Mutations in Primary Breast and Ovarian Carcinomas," Science 266:120-122 (1994).
Hall, J.M. et al., "Linkage of Early-Onset Familial Breast Cancer to Chromosome 17q21," Science 250:1684-1689 (1990).
Hu, H.M. et al., "A Novel RING Finger Protein Interacts with the Cytoplasmic Domain of CD40," J. Biol. Chem. 269(48):30069-30072 (1994).
Kallioniemi, A. et al., "Detection and mapping of amplified DNA squences in breast cancer by comparative genomic hybridization," Proc. Natl. Acad. Sci. USA 91:2156-2160 (1994).
Karlseder, J. et al., "Patterns of DNA Amplification at Band q13 of Chromosome 11 in Human Breast Cancer," Genes Chrom. Cancer 9:42-48 (1994).
Kirchweger, R. et al., "Patterns of Allele Losses Suggest the Existence of Five Distinct Regions of LOH on Chromosome 17 in Breast Cancer," Intl. J. Cancer 56(2):193-199 (1994).
Liebhaber, S.A. et al., "Characterization of a human cDNA encoding a widely expressed and highly conserved cystein-rich protein with an unusual zinc-finger motif," Nucl. Acids Res. 18(13):3871-3879 (1990).
Lonn, U. et al., "Intratumoral Heterogeneity for Amplified Genes in Human Breast Carcinoma," Intl. J. Cancer 58:40-45 (1994).
Lyon, M.F. & Kirby, M.C., "Mouse Chromosome Atlas," Mouse Genome 93(1):23-66 (Mar. 1995).
McGuire, W.L., "Adjuvant Therapy of Node-Negative Breast Cancer," New Eng. J. Med. 320(8):525-527 (1989).
Miki, Y. et al., "A Strong Candidate for the Breast and Ovarian Cancer Susceptibility Gene BRCA1," Science 266:66-71 (1994).
Muss, H.B. et al, "c-erbB-2 Expression and Response to Adjuvant Therapy in Women with Node-Positive Early Breast Cancer," N. Engl. J. Med. 330(18):1260-1266 (1994).
Okubo, K. et al., "Large Scale cDNA sequencing for analysis of quantitative and qualitative aspects of gene expression," Nat. Genetics 2(3):173-179 (1992).
Paterson, M.C. et al., "Correlation between c-erbB-2 Amplification and Risk of Recurrent Disease in Node-negative Breast Cancer," Cancer Res. 51(2):556-567 (1991).
Ravdin, P.M. & Chamness, G.C., "The c-erbB-2 proto-oncogene as a prognostic and predictive marker in breast cancer: a paradigm for the development of other macromolecular markers--a review," Gene 159(1):19-27 (Jun. 1995).
Razafimahatratra, P. et al., "Nucleotide sequence and expression of a maize H1 histone cNDA," Nucl. Acids Res. 19(7):1491-1496 (1991).
Regnier, C.H. et al., "Presence of a New Conserved Domain in CART1, a Novel Member of the Tumor Necrosis Factor Receptor-associated Protein Family, Which Is Expressed in Breast Carcinoma," J. Biol. Chem. 270(43):25715-25721 (Oct. 1995).
Reifenberger, G. et al., "Amplification of Multiple Genes from Chromosomal Region 12q13-14 in Human Malignant Gliomas: Preliminary Mapping of the Amplification Shows Preferential Involvement of CDK4, SAS, and MDM2,"Cancer Res. 54(16):4299-4303 (1994).
Rothe, M. et al., "A Novel Family of Putative Signal Transducers Associated with the Cytoplasmic Domain of the 75 kDa Tumor Necrosis Factor Domain," Cell 78:681-692 (1994).
Sillard, R. et al., "Chemical assay for cyst(e)ine-rich peptides detects a novel intestinal peptide ZF-1, homologous to a single zinc-finger motif," Eur. J. Biochem. 211(1/2):377-380 (1993).
Takeda, J. et al., "A molecular inventory of human pancreatic islets: sequence analysis of 1000 cDNA clones," Hum. Mol. Gen. 2(11):1793-1798 (1993).
Thomasetto, C. et al., "Identification of Four Novel Human Genes Amplified and Overexpressed in Breast Carcinoma and Localized to the q11-q21.3 Region of Chromosome 17," Genomics 28(3):367-376 (Aug. 1995).
Waye, M.M.Y. & Li, V.K.C., "Isolation of cDNA Clones From an Osteosarcoma-ROS17/2.8 Library by Differential Hybridization," J. Cell. Biochem. 54(3):273-280 (1994).
Weinstock, K.G. et al., "cDNA sequencing: a means of understanding cellular physiology," Curr. Opin. Biotech. 5(6):599-603 (1994).
Wilson, R. et al., "2.2. Mb of contiquous nucleotide sequence from chromosome III of C. elegens," Nature 368:32-38 (1994).
Yang, P. et al., "Molecular cloning and nucleotide sequences of cDNAs for histone H1 and H3B variants from wheat," Nucl. Acids Res. 19(18):5077 (1991).
Zou, Z. et al., "Maspin, a Serpin with Tumor-Suppressing Activity in Human Mammary Epithelial Cells," Science 263:526-529 (1994).
GenBank Accession No. D11736.
GenBank Accession No. D12116.
GenBank Accession No. D19971.
GenBank Accession No. D73047.
GenBank Accession No. D73326.
GenBank Accession No. D76021.
GenBank Accession No. D76362.
GenBank Accession Number F04305.
GenBank Accession Number F06105.
GenBank Accession Number M85471.
GenBank Accession No. M86141.
GenBank Accession No. N21784.
GenBank Accession No. R02020.
GenBank Accession No. R02021.
GenBank Accession No. R12544.
GenBank Accession No. R17500.
GenBank Accession No. R36697.
GenBank Accession No. R37445.
GenBank Accession No. R37545.
GenBank Accession No. R41043.
GenBank Accession No. R42594.
GenBank Accession No. R48774.
GenBank Accession No. R48877.
GenBank Accession No. R61143.
GenBank Accession No. R61861.
GenBank Accession No. S70803.
GenBank Accession No. T08349.
GenBank Accession N

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Isolated nucleic acid molecules useful as leukemia markers and i does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Isolated nucleic acid molecules useful as leukemia markers and i, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Isolated nucleic acid molecules useful as leukemia markers and i will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1454190

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.