Isolated nucleic acid molecules, peptides which form complexes w

Details Isolated nucleic acid molecules, peptides which form complexes w Isolated nucleic acid molecules, peptides which form complexes w

1997-08-21

1999-03-23

Chan, Christina Y.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

8 to 10 amino acid residues in defined sequence

530350, 536 235, C07H 2104, C07K 706, C07K 14705

Patent

active

058861459

ABSTRACT:
New tumor rejection antigen precursors, and the nucleic acid molecules which code for them, are disclosed. These tumor rejection antigen precursors are referred to as NAG tumor rejection antigen precursors, and the nucleic acid molecules which code for them are referred to as NAG coding molecules. Various diagnostic and therapeutic uses of the coding sequences and the tumor rejection antigen precursor molecules are described.

REFERENCES:
patent: 5620886 (1997-04-01), Brichard
Kawakami Y, et al., ndentification of a human melenoma antigen recognized tumor-infiltrating lymphocytes associated with in vivo tumor rejection. Proc. Natl. Acad. Sci. USA. 91:6458-6462, 1994.
Wolfel T, et al., Analysis of antigens recognized on human melanoma cells by A2-restricted cytolytic T lymphocytes (CTL). Int. J. Cancer. 55:237-244, 1993.
Atherton et al., "Peptide Synthesis. Part 2..sup.1 Procedures for Solid-Phase Synthesis Using N.sup..alpha. -Fluorenylmethoxycarbonylamino-Acids on Polyamide Supports. Synthesis of Substance P and of Acyl Carrier Protein 65-74 Decapeptide," J. Chem. Soc. Lond., I; 538-546 (1981).
Barinaga, "Getting Some Backbone.: How MHC Binds Peptides," Science, 257:880-881 (1992).
Boon et al., "Immunogenic Variants Obtained by Mutagenesis of Mouse Mastogytoma P815," J. Exp. Med., 152:1184-1193 (1980).
Chen et al., "Human Papillomavirus Type 16 Nucleoprotein E7 is a Tumor Rejection Antigen," Proc. Natl. Acad. Sci. USA, 88:110-114 (1991).
Coulie et al., "A New Gene Coding for a Differentiation Antigen Recognized by Autologous Cytolytic T Lymphocytes on HLA-A2 Melanomas," J. Exp. Med., 180:35-42 (1994).
Davis et al., Basic Methods in Molecular Biology, Elsevier, New York, 130-135 (1986).
Fremont et al., "Crystal Structures of Two Viral Peptides in Complex with Murine MHC Class I H-2K.sup.b," Science, 257:919-926 (1992).
Frohman et al., "Rapid Production of Full-Length cDNAs From Rare Transcripts: Amplification Using a Single Gene-Specific Oligonucleotide Primer," Proc. Natl. Acad. Sci. USA 85:8998-9002 (1988).
Greenberg, "Therapy of Murine Leukemia With Cyclophosphamide and Immune LYT-2.sup.+ Cells: Cytolytic T Cells Can Mediate Eradication of Disseminated Leukemia," The Journal of Immunology, 136:5:1917-1922 (1986).
Herin et al., "Production of Stable Cytolytic T-Cell Clones Directed Against Autologous Human Melanoma," Int. J. Cancer, 39:390-396 (1987).
Kast et al., "Eradication of Adenovirus E1-Induced Tumors by E1A-Specific by Cytotoxic L Lymphocytes," Cell, 59:603-614 (1989).
Latron et al., "A Critical Role for Conserved Residues in the Cleft of HLA-A2 in Presentation of a Nonapeptide to T Cells," Science, 257:964-967 (1989).
Lynch et al., "Immunotherapeutic Elimination of Syngeneic Tumors in vivo by Cytotoxic T Lymphocytes Generated in vitro From Lymphocytes From the Draining Lymph Nodes of Tumor-Bearing Mice," Eur. J. Immunol., 21:1403-1410 (1991).
Male et al., Advanced Immunology, J.P. Lipincott Company, (1987), pp. 6.1-10.16.
Maniatis et al., "Rapid Isolation of Plasmid or Bacteriophage .lambda. DNA," Cold Spring Harbor Laboratory, 365-369 (1982).
Matsumura et al., "Emerging Principles for the Recognition of Peptide Antigens by MHC Class I Molecules," Science, 247:927-934 (1992).
Pandolfino et al., "Specificity, T Cell Receptor Diversity and Activation Requirements of CD4.sup.+ and CD8.sup.+ Clones Derived From Human Melanoma-Infiltrating Lymphocytes," Eur. J. Immunol., 22:1795-1802 (1992).
Riddell et al., "Restoration of Viral Immunity in Immunodeficient Humans by the Adoptive Transfer of T Cell Clones," Science, 257:238-240 (1992).
Saito et al., "cDNA Cloning and Chromosomal Mapping of Human N-Acetylglucosaminyltransfrase V+," Biochemical and Biophysical Research Communication, 198:1:318-327 (1994).
Traversari et al., "Transfection and Expression of a Gene Coding for a Human Melanoma Antigen Recognized by Autologous Cytolytic T Lymphocytes," Immunogenetics, 35:145-152 (1992).
van der Bruggen et al., "A Gene Encoding an Antigen Recognized by Cytolytic T Lymphocytes on a Human Melanoma," Science, 254:1643-1647 (1991).
van den Eynde et al., "Presence on a Human Melanoma of Multiple Antigens Recognized by Autologous CTL," Int. J. Cancer, 44:634-640 (1989).
Viret et al., "Recognition of Shared Melanoma Antigen by HLA-A2 Restricted Cytolytic T Cell Clones Derived From Human Tumor-Infiltrating Lymphocytes," Eur. J. Immunol., 23:141-146 (1993).

Affiliated with

Also associated with

Rating

Isolated nucleic acid molecules, peptides which form complexes w does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Isolated nucleic acid molecules, peptides which form complexes w, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Isolated nucleic acid molecules, peptides which form complexes w will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2126717