Isolated nucleic acid molecules encoding P57KIP2

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

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536 221, 536 2431, 536 2433, 435 2402, 4353201, C07M 2102, C02H 2104, C12N 1570, C12N 121

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060254807

ABSTRACT:
This invention provides an isolated nucleic acid molecule encoding a mammalian p57.sup.KIP2. This invention also provides vectors comprising the isolated nucleic acid molecule encoding a mammalian p57.sup.KIP2. This invention further provides a host vector system for the production of a mammalian p57.sup.KIP2. This invention also provides probes for the isolated nucleic acid molecule encoding a mammalian p57.sup.KIP2. This invention provides antibodies directed against a mammalian p57.sup.KIP2. This invention also provides transgenic animals comprising isolated nucleic acid molecules encoding a mammalian p57.sup.KIP2. Finally, this invention provides different uses of the mammalian p57.sup.KIP2.

REFERENCES:
patent: 4683195 (1987-07-01), Mullis
patent: 4683202 (1987-07-01), Mullis
patent: 4745051 (1988-05-01), Smith et al.
patent: 5302706 (1994-04-01), Smith
Ausebel, F.M. et al., (1992) "Manipulation of Yeast Genes," Short Protocols in Molecular Biology, John Wiely & Sons, New York, 13-29 to 13-30 (Exhibit 5).
Auselbel, F.M., et al., (1995) Current Protocols in Molecular Biology, John Wiley & Sons, New York, 3.5.9-3.5.10 and 5.5.1-5.5.11 (Exhibit 6).
Bai, C. et al., (1994) "Human Cyclin F.," EMBO J., 13:6087-6098 (Exhibit 7).
Boshart, M. et al., (1985) A Very Strong Enhancer is Located Upstream of an Immediate Early Gene of Human Cytomegalovirus, Cell, 41:521 (Exhibit 8).
Breeden, L. and Nasmyth, K., (1985) "Regulation of the Yeast HO Gene," Cold Spring Harbor Symp. Quant. Biol., 50:643-650 (Exhibit 9).
Cairns, P. et al., (1994) "Rates of p16 [MTS1] Mutations in Primary Tumors with p9 Loss," Science, 265:415-417 (Exhibit 10).
Chamberlin, M. et al., (1970) "New RNA Polymerase from Escherichia coli Infected with Bacteriophage T7," Nature, 228:227-231 (Exhibit 11).
Dijkema, R. et al., 91985) "Cloning and Expression of the Chromosomal Immune Interferon Gene of the Rat," EMBO J., 4:761 (Exhibit 12).
Draetta, G., (19930 "Cdc2 Activation: The Interplay of Cyclin Binding and Thrl6l Phosphorylation," Trends Cell Biol., 3:287-289 (Exhibit 13).
Dulic, V. et al., (1994) "p53-Dependent Inhibition of Cyclin Dependent Kinase Activities in Human Fibroblasts During Radiation-Induced GI Arrest," Cell, 76:1013-1023 (Exhibit 14).
Durfee, T. et al., (1993) "The Retinoblastoma Protein associates With the Protein Phosphatase Type I Catalytic Subunit," Genes & Dev., 7:555-569 (Exhibit 15).
El-Diery, W.S., (1993) "WAF1, A Potential Mediator of p53 Tumor Suppression," Cell, 75:817-825 (Exhibit 16).
El-Diery, W.S., (1994) "WAF1/CIP1 is Induced in p53 Medicated G.sub.1 Arrest and Apoptosis.sup.1," Cancer Res., 54:1169-1174 (Exhibit 17).
Elledge, S.J. et al., (1992) "CDK2 Encodes a 33-kDa Cyclin A-Associated Protein Kinase and is Expressed Before CDC2 in the Cell Cycle," Proc. Natl. Acad. Sci. USA, 89:2907-2911 (Exhibit 18).
Erlich, H.A. (ed.), PCR Technology, (1989) "Taq DNA Polymerase," Stockton Press., 17-22 (Exhibit 20).
Florez-Rozas, H. et al., (1994) "Cdk-Interacting Protein-1 Directly Binds with Proliferating Cell Nuclear Antigen and Inhibits DNA Replication Catalyzed by the DNA Polymerase .delta. Holoenzyme," Proc. Natl. Acad. Sci. USA, 91:8655-8659 (Exhibit 21).
Gorman, C.M. et al., (1982) "The Rous Sarcoma Virus long Terminal Repeat is a Strong Promoter When Introduced into a Variety of Eukaryotic Cells by DNA-Mediated Transfection," Proc. Natl. Acad. Sci. USA, 79:6777 (Exhibit 22).
Graham and van der Eb, (1973) "A New Technique for the Assay of Infectivity of Human Adenovirus 5 DNA," Virol., 52:456-467 (Exhibit 23).
Guan, K. et al., (1994) "Growht Suppression by p18, a .sup.P16ink4b/MTS1 -and ph14.sup.INK4B/MTS2- -Related CDK6 Inhibitor, Correlates with Wild-Type pRb Function," Genes and Dev., 8:2939-2952 (Exhibit 24).
Gubler, U. and Hoffman, B.J., (1983) "A Simple and Very Efficient Method for Generating cDNA libraries," Gene, 25:263-269 (Exhibit 25).
Halvey,O., et al. (1995) "Correlation Terminal Cell Cycle Arrest of Skeletal Muscle with Induction of P21 by MyoD," Science, 267:1018-1021 (Exhibit 26).
Hannon, G.J. and Beach, D., (1994) "P15.sup.ink4b is a Potential Effector of TGF-.beta. Induced Cell Cycle Arrest," Nature, 371:257-261 (Exhibit 27).
Harlow, E. and Lane, E., (1988) Antibodies: A Laboratory Manual Cold Spring Harbor Press, New York, 117,119,498, 522:33 (Exhibit 28).
Harper et al., (1995) "Inhibition of Cyclin-dependent Kinases by p21," Mol. Bio. Cell, 6:387-400 (Exhibit 29).
Hastie, N.D., (1994) "The Genetics of Wilms Tumor-A Case of Disrupted Development," Genetics, 28:523-558 (Exhibit 30).
Hunter, T. and Pines, J., (1994) "Cyclins and Cancer II: Cyclin D and CDK Inhibitors Come of Age," Cell, 79:573-582 (Exhibit 31).
Ijdo, J.W. et al., (1992) "Multiple Variants in Subtelomeric Regions of Normal Karyotypes," Genomics, 14:1019-1025 (Exhibit 32).
Jen, J. et al., (1994) "Deletion of p16 and p15 Genes in Brian Tumors," Cancer Res., 54:6353-6358 (Exhibit 33).
Jiang, H. et al., (1994) "Induction of Differentiationin Human Promyelocytic HL-60 Leukemia Cells Activates p21, WAFI/CIP1, Expression in the Absence of p53," Oncogene, 9:3389-3396 (Exhibit 34).
Junien, C., (1992) "Beckwith-Wiedemann Syndrom, Tumourigenesis and Imprinting," Curr. Op. Genet. Dev., 2;431-438 (Exhibit 35).
Kacian, D.L. et al., (1972) "A Replicating RNA Molecule Suitable for a Detailed Analysis of Extracellular Evolution and Replication," Proc. Natl. Acad. Sci. USA, 69:3038-3042 (Exhibit 36).
Kato, J. et al., (1994) "Cyclic AMP-Induced GI Phase Arrest Mediated by an Inhibitor (p27.sup.Kip1) " Cell, 7:487-496 (Exhibit 37).
Kim, D.W. et al., (1990) "Use of the Human Elongation Factor 1.alpha. Promoter as a Versatile and Efficient Expression System," Gene, 91:217 (Exhibit 38).
Lutz, B. et al., (1994) "Development Regulation of the Orphan Receptor COUP-TF II Gene in Spinal Motor Neurons," Development, 120:25-36 (Exhibit 40).
Maniatis, T. et al., (1987) "Regulation of Inducible and Tissue-specific Gene Expression," Science, 236:1237 (Exhibit 41).
Martinez, J. et al., (1991) "Cellular Localization and Cell Cycle Regulation by a Temperature-Sensitive p53-Protein," Genes & Dev., 5:151-159 (Exhibit 42).
Matsushime, H. et al., (1992) "Identification and Properties of an atypical Catalytic Subunit (p34.sup.psk-J3 /cdk4) for Mamalian D-type GI Cyclins," Cell, 71:323-334 (Exhibit 44).
Meyerson, M. and Harlow, E., (1994) "Identification of GI Kinase Activity for cdk6, A Novel Cyclin D Partner," Mol. Cell. Biol., 14:2077-2086 (Exhibit 45).
Michieli, P. et al., (1994) "Induction of WAF1/CIP1 by a p53-Independent Pathway," Cancer Res., 54:3391-3395 (Exhibit 46).
Mizushima, S. and Nagata, S. (1990) "Pef-BOS, A Powerful Mammalian Expression Vector," Nuc. Acids. Res., 18:5322 (Exhibit 47).
Nasmyth, K. and Hunt, T., (1993) "Dams and Sluices," Nature, 366:634-635 (Exhibit 48).
Nohori, T.K. et al., (1994) "Deletions of the Cyclin-Dependent Kinase-4 Inhibitor Gene in Multiple Human Cancers," Nature, 368:753-756 (Exhibit 49).
Noda, A. et al., (1994) "Cloning of Senescent Cell-Derived Inhibitors of DNA Synthesis Using an Expression Cloning Screen," Exp. Cell. Res., 211:90-98 (Exhibit 50).
Nourse, J. et al., (1994) "Interleukin-2-Mediated Elimination of the p27.sup.Kip1 Cyclin-Dependent Kinase Inhibitor Prevented by Rapamycin," Nature, 372:570-573 (Exhibit 51).
Parker, S.B. et al., (1995) "p53-Independent Expression of p21.sup.Cip1 in Muscle and Other Terminally Differentiating Cells," Science, 267:1024-1027 (Exhibit 52).
Pettenatti, M.J. et al., (1986) "Beckwith-Wiedenmann Syndrome: Presentation of Clinical and Cytogenetic Data on 22 New Cases and Review of the Literature," Hum. Genet., 74:143-154 (Exhibit 53).
Pines, J., (1993) "Cyclins and Cyclin-Dependent Kinases: Take Your Partners," TIBS, 18:195-197 (Exhibit 54).
Sambrook, J. et al., (1989) Molecular Cloning: A Laboratory Manual, 2.sup.nd ed., Cold Spring Harbor Laboratory Press, New York, 1.33-1.48, 2.67-2.81, 2.108-2.111, 7.6-7.11, 7.39-7.52, 9.31-9.58 and 16.6-16.15 (Exhibit 55).
Seizinger, B. et al., (1991) "Report of the Committee on Chromosome and Gene Loss in Human Neoplasia," Cy

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