Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of...
Reexamination Certificate
2007-05-08
2007-05-08
Saoud, Christine J. (Department: 1647)
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
C435S006120, C435S007100, C435S069100, C435S252300, C435S320100, C530S350000, C536S023500
Reexamination Certificate
active
10465172
ABSTRACT:
The invention provides genetic approaches to inhibit or treat pain which employ mutant μ opioid receptors.
REFERENCES:
patent: 5591602 (1997-01-01), O'Dowd
patent: 5804595 (1998-09-01), Portoghese et al.
patent: 6235496 (2001-05-01), Yu
patent: 6270979 (2001-08-01), Sadee
patent: WO-98/02534 (1998-01-01), None
patent: WO-00/03024 (2000-01-01), None
Wells, J.A. (1990). Additivity of mutational effects in proteins. Biochemistry. 29(37):8509-8517.
Ngo et al. (1994). Computational complexity, protein structure prediction, and the Levinthal paradox. In Merz and Le Grand (Eds.) The Protein Folding Problem and Tertiary Structure Prediction. Birkhauser:Boston, pp. 491-495.
Phillips, A.J. (2001). The challenge of gene therapy and DNA delivery. J. Pharm. Pharmacology. 53:1169-1174.
Abrahams, Mark J., et al., “Emerging therapeutic strategies for chronic pain”,Emerging Drugs, 5 (4), Ashley Publications Ltd., (2000), 385-413.
Blomer, Ulrike, et al., “Highly efficient and sustained gene transfer in adult neurons with a lentivirus vector”,Journal of Virology. 71(9), (Sep. 1997), 6641-6649.
Carlezon, William A., et al., “Sensitization to morphine induced by viral-mediated gene transfer”,Science. 277(5327), (Aug. 8, 1997), 812-814.
Claude, Patricia A., “A Study of Antagonist-induced activation of Opioid Receptors with a Serine196 Mutation”,Ph.D. Thesis, University of Minnesota, (1997).
Claude, Patricia A., et al., “Mutation of a conserved serine in TM4 of opioid receptors confers full agonistic properties to classical antagonists”,Proceedings of the National Academy of Sciences of the United States of America. 93(12), (Jun. 1996), 5715-5719.
Kaspar, B. K., et al., “Adeno-associated virus effectively mediates conditional gene modification in the brain”,Proceedings of the National Academy of Sciences of the United States of America, 99(4), (Feb. 19, 2002), 2320-2325.
Kong, Haeyoung, et al., “A single residue, aspartic acid 95, in the delta opioid receptor specifies selective high affinity agonist binding”,Journal of Biological Chemistry. 268(31), (Nov. 5, 1993), 23055-23058.
Loh, Horace H., et al., “Opioid receptor knockout in mice: effects on ligand-induced analgesia and morphine lethality”,Brain Research. Molecular Brain Research. 54(2), (Mar. 1, 1998), 321-326.
Naldini, Luigi, et al., “Efficient transfer, integration, and sustained long-term expression of the transgene in adult rat brains injected with a lentiviral vector”,Proceedings of the National Academy of Sciences of the United States of America. 93(21), (Oct. 15, 1996), 11382-11388.
Walker, Ellen A., et al., “In vivo apparent affinity and efficacy estimates for mu opiates in a rat tail-withdrawal assay”,Psychopharmacology. 136(1), (Mar. 1998), 15-23.
Zimmerman, D. M., et al., “Use of beta-funaltrexamine to determine mu opioid receptor involvement in the analgesic activity of various opioid ligands”,Journal of Pharmacology&Experimental Therapeutics, 241(2), (May 1987), 374-378.
Miaskowski, Chirstine , et al., “Kappa- and delta-opioid agonists synergize to produce potent analgesia”,Brain Research. 509(1), (Feb. 12, 1990), 165-168.
Geppert Patricia A.
Guo Xiao-Hong
Law Ping-yee
Loh Horace H.
Yang Wanling
Lockard Jon M
Regents of the University of Minnesota
Saoud Christine J.
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