Chemistry: molecular biology and microbiology – Vector – per se
Patent
1995-02-06
1996-02-06
Low, Christopher S. F.
Chemistry: molecular biology and microbiology
Vector, per se
536 231, 536 235, 514 44, 4351723, 435 911, 435 914, 4352402, 4352523, 935 9, 935 10, 935 11, 935 24, C12N 1585, C12N 1512, C12N 1506
Patent
active
054895332
ABSTRACT:
The present invention relates to intercellular adhesion molecules (ICAM-2) which are involved in the process through which lymphocytes recognize and migrate to sites of inflammation as well as attach to cellular substrates during inflammation. The invention is directed toward such molecules, screening assays for identifying such molecules and antibodies capable of binding such molecules. The invention also includes uses for adhesion molecules and for the antibodies that are capable of binding them.
REFERENCES:
patent: 5284931 (1994-02-01), Springer et al.
Borrebaeck, C. A. K., Strategy for the production of human monoclonal antibodies using in vitro activated B cells, J. Immunol. Methods 123:157-165 (1989).
Rudinger, J., Characteristics of the amino acids as components of a peptide hormone sequence, in Parsons, J. A., ed., Peptide Hormones, University Park Press, Baltimore, pp. 1-7 (Jun. 1976).
Staunton et al. 1989 Nature, 339 61-64 (4 May 1989).
Staunton et al., 1988 Cell 52, 925-933.
Rothlein et al. 1986 J. Immunol. 137, 1270-1274.
Seed et al. 1987 Proc. Nat'l. Acad. Sci. USA. 84, 3365-3369.
Dustin Michael L.
Springer Timothy A.
Staunton Donald E.
Dana Farber Cancer Institute
Low Christopher S. F.
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