Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Reexamination Certificate
2010-03-01
2011-12-27
Saoud, Christine J (Department: 1647)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
C435S252300, C435S320100, C435S325000, C435S358000, C424S192100, C536S023400
Reexamination Certificate
active
08084234
ABSTRACT:
Modified chimeric polypeptides with improved pharmacokinetics are disclosed. Specifically, modified chimeric Flt1 receptor polypeptides that have been modified in such a way as to improve their pharmacokinetic profile are disclosed. Also disclosed are methods of making and using the modified polypeptides including but not limited to using the modified polypeptides to decrease or inhibit plasma leakage and/or vascular permeability in a mammal.
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Davis Samuel
Papadopoulos Nicholas J.
Yancopoulos George D.
Cottingham Frank R.
Gregg Valeta
Lockard Jon M
Regeneron Pharmaceuticals Inc.
Saoud Christine J
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