Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1997-11-12
2000-02-15
Hutzell, Paula K.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
530395, 435 71, 435 72, C07K 100, G01N 3353
Patent
active
060254742
ABSTRACT:
The invention relates to nucleic acid molecules which code for the tumor rejection antigen precursor MAGE-3. Also disclosed are vectors, cell lines, and so forth, which utilize the nucleic acid molecule, and optionally, molecules coding for human leukocyte antigen HLA-A1. Uses of these materials in therapeutic and diagnostic contexts are also a part of the invention.
REFERENCES:
Herin et al., "Production of Stable Cytolytic T-Cell Clones Directed Against Autologous Human Melanoma," Int. J. Cancer, 39:390-396 (1987).
Anichini et al., "Clonal Anaylsis of the Cytolytic T-Cell Response to Human Tumors," Immunlogy Today, 8:12:385-389 (1987).
De Plaen et al., "Immunogenic (Tum.sup.-) Variants of Mouse Tumor P815: Cloning of the Gene of Tum.sup.- Antigen P91A and Identification of the Tum.sup.- Mutation*," Proc. Natl. Acad. Sci. USA, 85:2774-2278 (Apr. 1988).
Van Den Eynde et al., "Presence on a Human Melanoma of Multiple Antigens Recognized by Autologous CTL," Int. J. Cancer, 44:634-640 (1989).
Van Der Bruggen et al., "A Gene Encoding An Antigen Recognized by Cytolytic T Lymphocytes on a Human Melanoma," Science, 254:1643-1647 (Dec. 1991).
Traversari et al., "A Nonapeptide Encoded by Human Gene MAGE-1 Is Recognized on HLA-A1 by Cytoltic T Lymphocytes Directed Against Tumor Antigen MZ2-E," J. Exp. Med., 176:1453-1457 (Nov. 1992).
Brasseur et al., "Human Gene MAGE-1, which Codes For a Tumor-Rejection Antigen, is Expressed by Some Breast Tumors," Int. J. Cancer, 52:839-841 (1992).
Traversari et al., "Transfection and Expression of a Gene Coding for a Human Melanoma Antigen Recognized by Autologous Cytolytic T Lymphocytes," Immunogenetics, 35:145-152 (1992).
Boon-Falleur Thierry
van den Bruggen Pierre
Van den Eynde Benoit
Hutzell Paula K.
Ludwig Institute for Cancer Research
Sun-Hoffman Lin
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