Isolated nucleic acid molecules coding for tumor rejection antig

Details Isolated nucleic acid molecules coding for tumor rejection antig Isolated nucleic acid molecules coding for tumor rejection antig

1994-09-30

1998-11-03

Feisee, Lila

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

435 691, 435325, 4353201, 4352523, 536 235, 530350, C12N 500, C07H 2104, C07K 1400

Patent

active

058307532

ABSTRACT:
A new family of tumor rejection antigen precursors, and the nucleic acid molecules which code for them, are disclosed. These tumor rejection antigen precursors are referred to as DAGE tumor rejection antigen precursors, and the nucleic acid molecules which code for them are referred to as GAGE coding molecules. Various diagnostic and therapeutic uses of the coding sequences and the tumor rejection antigens, and their precursor molecules are described.

REFERENCES:
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Traversari et al, "A Nonapeptide Encoded by Human Gene MAGE-1 Is-Recognized on HLA-A1 By Cytolytic T Lymphocytes, Directed Against Tumor Antigrn MZ2-E", J. Exp. Med. 176: 1453-1457 (Nov. 1992).
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