Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2007-04-03
2007-04-03
Harris, Alana M. (Department: 1643)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C536S001110, C536S018700, C536S022100, C536S023100, C435S069100, C435S320100, C435S325000, C530S300000, C530S350000
Reexamination Certificate
active
09579543
ABSTRACT:
The invention relates to nucleic acid molecules which code for the tumor rejection antigen precursor MAGE-4 and 41. Also disclosed are vectors, cell lines, and so forth, which utilize the nucleic acid molecule, and optionally, molecules coding for human leukocyte antigen HLA-A1. Use of these materials in therapeutic and diagnostic contexts are also a part of the invention.
REFERENCES:
Nucleic acid sequence alignment between SEQ ID NO: 13 and SEQ ID NO: 14 of U.S. Appl. No. 09/579,543 (filed May 26, 2000).
Zakut et al. Differential Expression of MAGE-1, -2, and -3 Messenger RNA in transformed and normal human cell lines. Cancer Research 53: 5-8, Jan. 1, 1993.
Kirkin et al. Melanoma-associated antigens recognized by cytotoxic T lymphocytes. APMIS 106: 665-679, 1998.
Brasseur et al. Human gene MAGE-1, which codes for a tumor-rejection antigen, is expressed by some breast tumors. Int. J. Cancer 52: 839-841, 1992.
Stevenson. Tumor Vaccines. The FASEB Journal 5: 2250-2257, Jun. 1991.
Boon et al. Tum- transplantation antigens, point mutations, and antigenic peptides: a model for tumor-specif transplantation antigens? Cancer Cells 1(1): 25-28, Sep. 1989.
De Plaen et al. Sturcutre, chromosomal localization, and expression of 12 genes of the MAGE family. Immunogenetics 40: 360-369, 1994.
Boon-Falleur Thierry
Guagler Béatrice
van den Eynde Benoit
van der Bruggen Pierre
Fulbright & Jaworski LLP
Harris Alana M.
Ludwig Institute for Cancer Research
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