Isolated nucleic acid molecule which codes for a tumor rejection

Details Isolated nucleic acid molecule which codes for a tumor rejection Isolated nucleic acid molecule which codes for a tumor rejection

1994-06-03

1996-12-31

Jones, W. Gary

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

536 231, 536 2433, 4353201, 4352523, 43525233, C12Q 168, C07H 2104, C07H 2102, A61K 3900

Patent

active

055893341

ABSTRACT:
A nucleic acid molecule which codes for a tumor rejection antigen precursor which is in turn processed to an antigen presented by HLA-B44 molecule is described. The antigen is also described. These materials are useful in diagnostic and therapeutic methodologies. The tumor rejection antigen precursor is not tyrosinase, which has previously been identified as a tumor rejection antigen precursor processed to an antigen presented by HLA-B44.

REFERENCES:
patent: 5342774 (1994-08-01), Boon et al.
Hans Schreiber, In Fundamental Immunology 2nd Edition, Ed by William E. Paul, Raven Press, Ltd., N.Y., 1989, pp. 924-955.
Van der Bruggen et al., "A Gene Encoding an Antigen Recognized By Cytolytic T Lymphocytes On a Human Melanoma", Science, 254:1643-1647 (Dec. 1991).
Khanna et al., "Localization of Epstein-Barr Virus Cytotoxic T Cell Epitopes Using Recombinant Vaccinia: Implications for Vaccine Development", J. Exp. Med., 176: 169-176 (Jul. 1992.

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