Isolated nucleic acid molecule which codes for a 32 kDa protein

Details Isolated nucleic acid molecule which codes for a 32 kDa protein Isolated nucleic acid molecule which codes for a 32 kDa protein

1995-01-20

1998-03-24

Ulm, John

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

435 691, 4353201, 536 235, 536 2431, C12N 1512, C12N 510

Patent

active

057311951

ABSTRACT:
In accordance with this invention, an RPE cell membrane associated protein which has a molecular weight of about 32 kd, as determined by SDS-PAGE, has now been discovered. This protein, referred to an "p32," forms an oligomeric protein complex with the previously characterized p63 protein, a component of the membrane receptor for RBP. A nucleic acid molecule which codes for the p32 protein has also been isolated and sequence analysis shows that the p32 protein belongs to the family of short chain alcohol dehydrogenases, and exhibits 11-cis retinol dehydrogenase activity, the enzyme which catalyzes conversion of 11-cis-retinol into 11-cis retinaldehyde.

REFERENCES:
patent: 5177197 (1993-01-01), Kanzaki et al.
B.ang.vik et al., J. Biol. Chem., 267: 23035-23042 (1992).
B.ang.vik et al., J. Biol. Chem., 268: 20540-20546 (1993).
B.ang.vik et al., J. Biol. Chem. 266: 14978-14985 (1991).
Suzuki et al., Chimica et Biophysica Acta; 1163: 201-208 (1993).

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