Isolated nucleic acid molecule comprising the amino acid...

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S069100, C435S320100, C435S325000

Reexamination Certificate

active

08067562

ABSTRACT:
The present invention provides novel activin IIB5 receptor polypeptides capable of binding and inhibiting the activities of activin A, myostatin, or GDF-11. The present invention also provides polynucleotides, vectors and host cells capable of producing the receptor polypeptides. Compositions and methods for treating muscle-wasting, metabolic and other disorders are also provided.

REFERENCES:
patent: 5885794 (1999-03-01), Mathews et al.
patent: 6162896 (2000-12-01), Mathews et al.
patent: 6812339 (2004-11-01), Venter et al.
patent: 6891082 (2005-05-01), Lee et al.
patent: 2004/0223966 (2004-11-01), Wolfman et al.
patent: 2005/0186593 (2005-08-01), Mathews et al.
patent: 2006/0068468 (2006-03-01), Knopf et al.
patent: WO 00/43781 (2000-07-01), None
Wells, Biochemistry 29:8509-8517, 1990.
Ngo et al., The Protein Folding Problem and Tertiary Structure Prediction, pp. 492-495, 1994.
Wang et al. Nucl. Acids Res. 27: 4609-4618, 1999.
Kaufman et al., Blood 94: 3178-3184, 1999.
Wigley et al. Reprod Fert Dev 6: 585-588, 1994.
Campbell et al. Theriogenology 47(1): 63-72, 1997.
Phillips, A., J Pharm Pharmacology 53: 1169-1174, 2001.
Longfellow et al, Biochemistry, 29: 278-285, 1990.
Harrison, C.A., et al., “Antagonists of activin signaling: mechanisms and potential biological applications,”Trends in Endocrinology and Metabolism16(2):73-78, Mar. 2005.
Lee, S. and McPherron, A.C., “Regulation of myostatin activity and muscle growth,”Proc. Natl. Acad. Sci. USA98(16):9306-9311, Jul. 2001.
Lee, S., et al., “Regulation of muscle growth by multiple ligands signaling through activin type II receptors,”Proc. Natl. Acad. Sci. USA102(50):18117-18122, Dec. 2005.
Tobin, J.F., and Celeste, A.J., “Myostatin, a negative regulator of muscle mass: implications for muscle degenerative diseases,”Current Opinion in Pharmacology, Elsevier Science Publishers5(3):328-332, Jun. 2005.
Database EMBL Accession No. AY421275, Dec. 13, 2003, “Homo sapiensACVR2B gene, Virtual Transcript, partial sequence, genomic survey sequence.”
Database Geneseq Accession No. AAW86245, Feb. 16, 1999, “Mouse ActRIIB4 receptor protein.”
Database Geneseq Accession No. ADO43580, Jul. 29, 2004, “Amino acid sequence of ActRIIB.”
International Search Report, PCT/US2006/043044, mailed Mar. 15, 2007.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Isolated nucleic acid molecule comprising the amino acid... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Isolated nucleic acid molecule comprising the amino acid..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Isolated nucleic acid molecule comprising the amino acid... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4303335

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.