Isolated nucleic acid molecule coding for tumor rejection antige

Details Isolated nucleic acid molecule coding for tumor rejection antige Isolated nucleic acid molecule coding for tumor rejection antige

1997-04-25

2000-02-22

Hutzell, Paula K.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing saccharide radical

536 231, 435 691, 435 911, 4352523, C12P 1924

Patent

active

060279249

ABSTRACT:
The invention relates to an isolated DNA sequence which codes for an antigen expressed by tumor cells which maybe recognized by cytotoxic T cells, leading to lysis of the tumor cells which express it. This invention also relates to vectors which are designed to encode the antigen expressed by tumor cells and also to cells transfected by the DNA sequence or vectors which comprise the DNA sequence. Various therapeutic and diagnostic uses arising out of the properties of the DNA and the antigen for which it codes are also part of this invention.

REFERENCES:
De Plaen et al. GenBank Accession No. W10694-in MPSRCH search, 1994.
De Plaen et al. GenBank Accession No. W10685 in MPSRCH search, 1994.
Watson et al, eds, Mol. Biol of the Genes, pp. 1074-1075, 1987.
Townsend et al., The Epitopes of Influenza Nucleoprotein Recognized by Cytotoxic T Lymphocytes Can Be Defined With Short Synthetic Peptides, Cell 44:959-968 (1986).
Bjorkman et al., The foreign antigen binding site and T cell recognition regions of claim I histocompatibility antigens, Nature 329:512-518 (1987).
Van der Bruggen et al., A Gene Encoding an Antigenic Recognized by Cytolytic T Lymphocytes on a Human Melanoma, Science 254:1643-1647 (1991).
Traversari et al., A Nonapeptide Encoded by Human Gene MAGE-1 Is Recognized on HLA-A1 by Cytolytic T Lymphocytes Directed Against Tumor Antigen MZ2-E, J. Exp. Med. 176:1453-1457 (1992).
Ruppert et al., Prominent Role of Secondary Anchor Residues in Peptide Binding to HLA-A2.1 Molecules, Cell 74:929-937 (1992).
Celis et al., Induction of anti-tumor cytotoxic T lymphocytes in normal humans using primary cultures and synthetic peptide epitopes, Proc. Natl. Acad. Sci. USA 91:2105-2109 (1994).
Coulie et al., A New Gene Coding For A differentiation Antigen Recognized By Autologous Cytolytic T Lymphocytes on HLA-A2 Melanomas, J. Exp. Med. 180:35-42 (1994) (Not Prior Art).
Engelhard et al., Structure of Peptides Associated With Class I and Class II MHC Molecules, Ann. Rev. Immunol. 12:181-207 (1994).
DeSmet et al., Sequence and expression pattern of the human MAGE-2 gene, Immunogenetics 39:121-129 (1994).
Ding et al., Cloning And Analysis of MAGE-1 Related Genes, Biochem & Biophy. Res. Commun. 202(1): 549-555 (1994).
Van der Bruggen, et al. A peptide encoded by human gene MAGE-3 and presented by HLA-A2 induces cytolytic T lymphocytes that recognize tumor cells expressing MAGE-3, Eur. J. Immunol. 24:3038-3043 (1994).
A.G. Dalgleish, et al., Tumor Immunology, Cancer Clinical Science in Practice, (1994).
De Plaen, et al., Structure, chromosomal localization, and expression of 12 genes of the Mage family, Immunogenetics 40:360-369 (1994).
M. Hubank, et al., Identifying differences in mRNA expression by representational difference analysis of cDNA, Nucleic Acids Research 22: 25:5640-5648 (1994).
Sawbrook et al. (eds) Mol. Cloning, p. 11.45, 1987.
Sawbrook et al. (eds) Mol. Cloning, p. 14.2, 1987.

Affiliated with

Also associated with

Rating

Isolated nucleic acid molecule coding for tumor rejection antige does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Isolated nucleic acid molecule coding for tumor rejection antige, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Isolated nucleic acid molecule coding for tumor rejection antige will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-519708