Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of...
Patent
1997-04-11
2000-03-14
Degen, Nancy
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
4353201, 435366, 536 231, 536 235, 536 2431, C12N 1585, C12N 1563, C07H 2104
Patent
active
060371730
ABSTRACT:
The invention provides nucleic acids encoding a TRBP polypeptide, fragments thereof and homologs thereof The invention also provides TRBP polypeptides, fragments thereof and homologs thereof, and TRBP binding proteins. Methods for treating diseases or conditions characterized by an aberrant TRBP activity, e.g., by administering to the subject a TRBP therapeutic, are also disclosed. Diseases or conditions that can be treated according to the methods of the invention include thyroid-related disorders, metabolic disorders, and diabetes. Also disclosed are methods for predicting whether a subject is at risk of developing a disease associated with an aberrant TRBP activity, by determining, e.g., whether the subject has a genetic lesion in a TRBP gene and assays for identifying TRBP therapeutics.
REFERENCES:
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White, Genbank, Accession #Z93097, Mar. 20, 1997.
Woon Lee et. al., Interaction of Thyroid-Hormone Receptor with a Conserved Transcriptional Mediator, Nature, vol. 374, pp. 91-94 (Mar. 1995).
Woon Lee et. al., "Two Classes of Proteins Dependent on Either the Presence or Absence of Thyroid Hormone for Interaction with the Thyroid Hormone Receptor", Molecular Endocrinolgy, vol. 9, No. 2, pp. 244-254 (1995); and.
Zhang et. al., "Ligant-dependent Cross-talk between Steroid and Thryoid Hormone Receptors", The Journal of Biological Chemistry, vol. 271, No. 25, pp. 14825-14838 (Jun. 21, 1996).
Arnold, Esq. Beth E.
Clauss Isabelle M.
Degen Nancy
Millennium Pharmaceuticals Inc.
Wang Andrew
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