Isolated nucleic acid encoding the alpha subunit of the human le

Details Isolated nucleic acid encoding the alpha subunit of the human le Isolated nucleic acid encoding the alpha subunit of the human le

1993-05-27

1995-03-07

Draper, Garnette D.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 2351, 4353201, 530399, C07H 1700, C12N 1500, A61K 3700, C07K 1300

Patent

active

053959299

ABSTRACT:
This invention concerns the cloning of the alpha-subunit of the p150,95 leukocyte adhesion receptor molecule. The invention also concerns the alpha-subunit of p150,95, as well as fragments of this receptor molecule. The invention further pertains to the diagnostic and therapeutic uses for such molecules.

REFERENCES:
patent: 4761371 (1988-08-01), Bell et al.
patent: 4935234 (1990-06-01), Todd, III et al.
patent: 4956281 (1990-09-01), Wallner et al.
Anderson et al. Jul. 1986, J. Immunol. 137:15-27.
Lathe, 1985, J. Mol. Biol. 183:1-12.
Miller et al. Apr. 1987, J. Immunol. 138:2381-2383.
Yang et al. Oct. 1986, Cell 47:3-10.
Young et al. 1983, PNAS USA 80:1194-1198.
Anderson, D. C. et al., Abnormalities of Polymorphonuclear Leukocyte Function Associated with a Heritable Deficiency of High Molecular Weight Surface Glycoproteins (GP 138): Common Relationship to Diminished Gell Adherence, J. Clin. Invest. 74:536-551 (Aug. 1984).
Anderson, D. C. et al., Contributions of The Mac-1 Glycoprotein Family to Adherence-Dependent Granulocyte Functions: Structure-Function Assessments Employing Subunit-Specific Monoclonal Antibodies, J. Immunol. 137(1):15-27 (Jul. 1, 1986).
Anderson, D. C. et al., The Severe and Moderate Phenotypes of Heritable Mac-1, LFA-1 Deficiency: Their Quantitative Definition and Relation to Leukocyte Dysfunction and Clinical Features, J. Inf. Dis. 152(4):668-689 (Oct. 1985).
Beller, D. I. et al., Anti-Mac-1 Selectively Inhibits the Mouse and Human Type Three Complement Receptor, J. Exp. Med. 156:1000-1009 (Oct. 1982).
Brian, A. A. et al., Allogeneic stimulation of cytotoxic T cells by supported planar membranes, Proc. Natl. Acad. Sci. USA 81:6159-6163 (Oct. 1984).
Bullock, W. E. et al., Role of the Adherence-Promoting Receptors, CR3, LFA-1, and p150,95, In Binding of Histoplama capsulatum by Human Macrophages, J. Exp. Med. 165:195-210 (Jan. 1987).
Cerf-Bensussan, N. et al., Immunohistologic and Immunoelectron Microscopic Characterization of the Mucosal Lymphocytes of Human Small Intestine by the Use of Monoclonal Antibodies, J. Immunol. 130(6):2615-2622 (Jun. 1983).
Corbi, A. et al., cDNA Cloning and Primary Sequence of the Alpha Subunit of p150,95, J. Cell. Biochem. Suppl. 11D, p. 268, Abstract No. T404 (1987).
Corbi, A. L. et al., cDNA cloning and complete primary structure of the .alpha. subunit of a leukocyte adhesion glycoprotein p150,95, EMBO J. 6(13):4023-4028 (1987).
Cunningham, B. A. et al., Neural Cell Adhesion Molecule: Structure, Immunoglobulin-Like Domains, Cell Surface Modulation, and Alternative RNA Splicing, Science 236:799-806 (May 15, 1987).
Dana, N. et al., Two Functional Domains in the Phagocyte Membrane Glycoprotein Mo1 Identified with Monoclonal Antibodies, J. Immunol. 137(10):3259-3263 (Nov. 15, 1986).
Davingnon, D. et al., Lymphocyte function-associated antigen 1 (LFA-1): A surface antigen distinct from Lyt-2, 3 that participates in T lymphocyte-mediated killing, Proc. Natl. Acad. Sci. USA 78(7):4535-4539 (Jul. 1981).
Detmers, P. A. et al., Aggregation of Complement Receptors on Human Neutrophils in the Absence of Ligand, J. Cell Biol. 105:1137-1145 (1987).
Dustin, M. L., et al., Induction by IL 1 and Interferon-.gamma.: Tissue Distribution, Biochemistry and Function of a Natural Adherence Molecule (ICAM-1), J. Immunol. 137(1):245-254 (Jul. 1, 1986).
Dustin, M. L. et al., Purified Lymphocyte Function-Associated Antigen 3 Binds to CD2 and Mediates T Lymphocytes Adhesion, J. Exp. Med. 165:677-692 (Mar. 1987).
Fischer, A. et al., Prevention of Graft Failure by an Anti-HLFA-1 Monoclonal Antibody in HLA-Mismatched Bone-Marrow Transplatation, Lancet:1058-1061 (Nov. 8, 1986).
Fischer, A. et al., Role of the LFA-1 Molecular in Cellular Interactions Required for Antibody Production in Humans, J. Immunol. 136(9):3198-3203 (May 1, 1986).
Gay, D. et al., The Major Histocompatibility Complex-Restricted Antigen Receptor on T Cells, J. Immunol. 136(6):2026-2032 (Mar. 15, 1986).
Grossman, H. B., Clinical Applications of Monoclonal Antibody Technology, Urologic Clinics of North America 13(3):465-474 (Aug. 1986).
Harlan, J. M. et al., The Role of Neutrophil Membrane Glycoprotein GP-150 in Neutrophil Adherence to Endothelium In Vitro, Blood 66(1):167-178 (Jul. 1985).
Haskard, D. et al., T Lymphocyte Adhesion to Endothelial Cells: Mechanisms Demonstrated by Anti-LFA-1 Monoclonal Antibodies, J. Immunol. 137(9):2901-2906 (Nov. 1986).
Hogg, N. et al., The p150,95 molecule is a marker of human mononuclear phagocytes: comparison with expression of class II molecules, Eur. J. Immunol. 16:240-248 (1986).
Hynes, R. O. Integrins: A Family of Cell Surface Receptors, Cell 48:549-554 (Feb. 27, 1987).
Jones, D. H. et al., Subcellular Location of MAC-1 (CR-3) in Human Neutrophils: Effects of Chemotactic Factors and PMA, Ped. Res. 21:312a, Abstract No. 835 (1987).
Keizer, G. D. et al., Biochemical and functional characteristics of the human leukocyte membrane antigen family LFA-1, Mo-1, and p150,95, Eur. J. Immunol. 15:1142-1147 (1985).
Keizer, G. D. et al., Membrane Glycoprotein p150,95 of Human Cytotoxic T Cell Clones is Involved in Conjugate Formation with Target Cells, J. Immunol. 138(10):3130-3136 (May 15, 1987).
Keizer, G. D. et al., Role of p150,95 in adhesion, migration, chemotaxis and phagocytosis of human monocytes, Eur. J. Immunol. 17:1317-1322 (1987).
Khaw, B. A. et al., Myocardial Infarct Imaging of Antibodies to Canine Cardiac Myosin with Indium-111-Diethylenetriamine Pentaacetic Acid, Science 209:295-297 (Jul. 11, 1980).
King, J., Deciphering the Rules of Protein Folding, C&EN, pp. 32-54 (Apr. 10, 1989).
Kishimoto, T. K. et al., Cloning of the .beta. Subunit of the Leukocyte Adhesion Proteins: Homology to an Extracellular Matrix Receptor Defines a Novel Supergene Family, Cell 48:681-690 (Feb. 27, 1987).
Kishimoto, T. K. et al., Cloning of the .beta. Subunit of LFA-1 Mac-1, and p150,95: Homology to a fibronectin receptor and the molecular basis of leukocyte adhesion deficiency, Fed. Proc. 46:446, Abstract No. 755 (Mar. 1987).
Kishimoto, T. K. et al., The .beta. Subunit of LFA-1, Mac-1, and p150,95: Gene Cloning, Homology to a Fibronectin Receptor, and the Molecular Basis of Leukocyte Adhesion Deficiency, J. Cell. Biochem., Suppl. 11D, p. 271, Abstract No. T415 (1987).
Kohl, S. et al., The Genetic Deficiency of Leukocyte Surface Glycoprotein Mac-1, LFA-1, p150,95 in Humans is Associated with Defective Antibody-Dependent Cellular Cytotoxicity In Vitro and Defective Protection Against Herpes Simplex Virus Infection In Vivo, J. Immunol. 137:1688-1694 (Sep. 1, 1986).
Krensky, A. M. et al., LFA-1, LFA-2 and LFA-3 Antigens are Involved in CTL-Target Conjunction, J. Immunol. 132(5):2180-2182 (May 1984).
Lanier, L. L. et al., p.150/95, Third member of the LFA-1/CR.sub.3 polypeptide family identified by anti-Leu M5 monoclonal antibody, Eur. J. Immunol. 15:713-718 (1985).
Lathe, R., Synthetic Oligonucleotide Probes Deduced from Amino Acid Sequence Data, Theoretical and Practical Considerations, J. Mol. Biol., 183:1-12 (1985).
Marlin, S. D. et al., Purified Intercellular Adhesion Molecule-1 (ICAM-1) is a Ligand for Lymphocyte Function-Associated Antigen 1 (LFA-1), Cell 51:813-819 (Dec. 4, 1987).
Martz, E., Immune T Lymphocyte to Tumor Cell Adhesion, J. Cell Biol. 84:584-598 (Mar. 1980).
Micklem, K. J. et al., Isolation of complement-fragment-iC3b-binding proteins by affinity chromatography, Biochem. J. 231:233-236 (1985).
Miller, L. J. et al., Regulated Expression of the Mac-1, LFA-1, p150,95 Glycoprotein Family During Leukocyte Differentiation, J. Immunol. 137(9):2891-2900 (Nov. 1, 1986).
Mosser, D. M. et al., The Mouse Macrophage Receptor for C3bi (CR3) is a Major Mechanism in the Phagocytosis of Leishmania Promastigotes, J. Immunol. 135(4):2785-2789 (Oct. 1985).
Patarroyo, M. et al., Identification of a novel adhesion molecules in human leukocytes by monoclonal antibody LB-2, FEBS Letters 210(2):127-131 (Jan. 1987).
Patarroyo, M. et al., Identification of a Cell-Surface Glycoprotein Mediating Cell Adhesion in EBV-Immortalized Normal B Cells, Int. J. Cancer 38:539-547 (1986).
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