Isolated nucleic acid encoding receptor-like TGF-.beta.1 binding

Details Isolated nucleic acid encoding receptor-like TGF-.beta.1 binding Isolated nucleic acid encoding receptor-like TGF-.beta.1 binding

1995-12-05

1998-03-24

Fitzgerald, David L.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Primate cell, per se

435 691, 435325, 435365, 536 235, C07M 2104, C07K 1471, C07K 14715, C12N 1512

Patent

active

057312001

ABSTRACT:
The invention relates to a family of substantially pure, receptor like TGF-.beta.1 binding glycoproteins. These molecules are characterized by molecular masses of 160 kd, 70-80 kd, and 30-40 kd as determined by SDS-PAGE, and the ability to bind the TGF-.beta.1 molecule. This family of molecules is useful in identifying and/or quantifying TGF-.beta.1 in a sample, as well as inhibiting its effect on cells. Also described are nucleic acid sequences which code for the protein monomer making up the molecules.

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