Chemistry: molecular biology and microbiology – Vector – per se
Reexamination Certificate
2005-04-26
2005-04-26
McKelvey, Terry (Department: 1636)
Chemistry: molecular biology and microbiology
Vector, per se
C536S023500
Reexamination Certificate
active
06884617
ABSTRACT:
The present invention relates generally to a regulatory molecule and to genetic sequences encoding same. More particularly, the present invention provides a molecule involved in, associated with or which otherwise facilitates myogenesis. In a particularly preferred embodiment, the regulatory molecule is a transcription factor involved in the expression of genes resulting in the determination of skeletal muscle (a sequence encoding the regulatory molecule is disclosed within the specification as Seq. Id. No: 2). The identification of the regulatory molecule of the present invention permits the development of agents capable of modulating myogenesis including therapeutic agents capable of ameliorating aberrations in pyogenesis such as but not limited to myogenic cancers.
REFERENCES:
patent: 5795723 (1998-08-01), Tapscott et al.
patent: 5885797 (1999-03-01), Chen et al.
patent: WO 9716548 (1997-05-01), None
patent: WO 9813491 (1998-04-01), None
patent: WO 9827206 (1998-06-01), None
Massari, et al. (1998) “Characterization of ABF-1, a Novel Basic Helix-Loop-Helix Transcription Factor Expressed in Activated B Lymphocytes” Mol. and Cell. Bio. 18:3130-3139.
Robb, et al. (1998) “Musculin: a Murine Basic Helix-Loop-Helix Transcription Factor Gene Expressed in Embryonic Skeletal Muscle” Mechanisms of Dev. 76:197-201.
Akazawa et al. (1995) “A Mammalian Helix-Loop-Helix Factor Structurally Related to the Product ofDrosophilaProneural Gene atonal Is a Positive Transscriptional Regulator Expressed in the Developing Nervous System” J. Biol. Chem. 270(15): 8730-8738.
Begley et al. (1992) “Molecular Characterization of NSCL, a Gene Encoding a Helix-Loop-Helix Protein Expressed in the Developing Nervous Systems” Proc. Natl. Acad. Sci. USA 89:38-42.
Burgess et al. (1995) “Paraxis: A Basic Helix-Loop-Helix Protein Expressed In Paraxial Mesoderm and Developing Somites” Dev. Biol. 168: 296-306.
Cserjesi et al. (1995) “Scleraxis: a Basic Helix-Loop-Helix Protein that Prefigures Skeletal Formation During Mouse Embryogenesis” Development 121: 1099-1110.
Davis et al. (1987) “Expression of a Single Transfected cDNA Converts Fibroblasts to Myoblasts” Cell 51: 987-1000.
Edmondson et al. (1989) “A gene with homology to the myc similarity region of MyoD1 is expressed during myogenesis and is sufficient to activate the muscle differentiation program” Genes & Development 3:628-640.
Georgia et al. (1997) “A Basic-Helix-Loop-Helix Protein Expressed in Precursors ofDrosophlaLongitudinal Visceral Muscles” Mech. Devel. 69: 115-124.
Jan et al. (1993) “HLH Proteins, Fly Neurogenesis, and Vrtebrate Myogenesis” Cell 75:827-830.
Lyons et al. (1995) “Myogenic and Morphogenetic Defects In the Heart Tubes of Murine Embryos Lacking the Homeo Box Gene Nkx2-5” Genes and Development 9:1654-1666.
Molkentin et al. (1995) “A Calcineurin-Dependent Transcriptional Pathway for Cardiac/Hypertrophy” Cell 93: 215-228.
Murre et al. (1994) “Structure and Function of Helix-Loop- Helix Proteins” Biochimica et Biophysica Acta 1218: 125-135.
Murre et al. (1989) “A New DNA Binding and Dimerizaton Motif In Immunoglobulin Enhance Binding, Daughterless, MyoD, and myc Proteins” Cell 56: 777-793.
Robb et al. (1996) “Structural Analysis of the Gene Encoding the Murine Interleukin-11 Receptor α-Chain and a Related Locus” J. Biol. Chem. 271 (23): 13754-13761.
Robb et al. (1998) “Infertility in Female Mice Lacking the Receptor for Interleukin 11 is Due to a Defective Uterne Response to Implantation” Nature Medicine 4(3):303-307.
Srivastava et al. (1995) “A Subclass of bHLH Proteins Required for Cardiac Morphogenesis” Science 270: 1995-1999.
Tajbakhsh et al. (1998) “Somite Development: Constructing the Vertebrate Body” Cell 92: 9-16.
Voronova et al. (1990) “Mutations that disrupt DNA binding and dimer formation in the E47 helix-loop-helix protein map to distinct domains” Proc. Natl. Acad. Sci. USA 87: 4722-4726.
Wolf et al. (1991) “The M-Twist Gene of Mus is Expressed in Subsets of Mesodermal Cells and Is Closely Related to the Xenopus X-twi and theDrosophilatwist Genes” Developmental Biology 143:363-373.
Begley Glenn C.
Harvey Richard P.
Robb Lorraine
Duane Morris LLP
McKelvey Terry
Walter and Eliza Hall Institute of Medical Research
LandOfFree
Isolated nucleic acid encoding murine musculin does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Isolated nucleic acid encoding murine musculin, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Isolated nucleic acid encoding murine musculin will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3427845