Isolated nucleic acid encoding L-lysine: 2-oxoglutaric acid...

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing alpha or beta amino acid or substituted amino acid...

Reexamination Certificate

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C435S110000, C435S183000, C435S193000, C435S252300, C435S252330, C435S320100, C536S023100, C536S023200

Reexamination Certificate

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10859149

ABSTRACT:
Provided are an isolated gene capable of participating in the production of L-homoglutamic acid, and a production system of L-homoglutamic acid by using this gene. The gene is derived from the genome ofFlavobacterium lutescens.

REFERENCES:
patent: 96/31616 (1996-10-01), None
Coque et al. J Bacteriol. Oct. 1991; 173(19):6258-64.
T. Yagi et al., “L-Lysine: 2-Oxoglutarate 6-Aminotransferase”, J. Biochem. (1980), vol. 87, No. 5, pp. 1395-1402.
T. Yagi et al., “A Novel Purification Procedure of L-Lysine 6-Aminotransferase fromFlavobacterium lutescence”, Biochem., Biophys, Acta. (1980), vol. 614, No. 1, pp. 63-70.
J.R. Coque et al., “A Gene Encoding Lysine 6-Aminotransferase, Which Forms the β-Lactam Precursor α-Aminoadipic Acid, is Located in the Cluster of Cephamycin Biosynthetic Genes inNocardia lactamdurans”, J. Bioteriol. (1991), vol. 173, No. 19, pp. 6258-6264.
K. Madduri et al., “Cloning of Location of a Gene Governing Lysine ε-Aminotransferase, an Enzyme Initialing β-Lactum Biosynthesis inStreptomyces spp.”, J. Bioteriol. (1991), vol. 173, pp. 985-988.
J.F. Martin et al., “Genes for β-Lactum Antibiotic Biosynthesis”, Antonie van Leeuwenhoek (1995), vol. 181, Nol 2, pp. 181-200.
A.L. Leitao et al., “Inducing Effect of Diamines on Transcription of the Cephamycin C Genes from the lat and pcbAB Promoters inNocardia lactamdurans” J. Bacteriol. (Apr. 1999), vol. 181, No. 8, pp. 2379-2384.
J.P. Francisco et al., “The pcd Gene Encoding Piperideine-6-Carboxylate dehydrogenase involved in Biosynthesis of α-Aminoadipic Acid is Located in the Cephamycin Cluster ofStreptomyces clavuligerus”, J. Bacteriol, (Sep. 1998) vol. 180, No. 17, pp. 4753-4756.
L.F. Juan et al., “Δ-1-Piperideine-6-carboxylate dehydrogenease, a new enzyme that forms α-aminoadipate inStreptomyces clavuligerusand other cephamycin c-producing actinomycetes”, Biochem. J. (1997), vol. 327, No. 1, pp. 59-64.
Attwood, “Which craft is best in bioinformatics?”, Comput. Chem., 2001, vol. 25, No. 4, pp. 329-339.
C.P. Ponting, “Issues in predicting protein function from sequence”, Brief Bioinform., Mar. 2001, vol. 21, No. 1, pp. 19-29.

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