Isolated nonapeptides which bind to HLA molecules and provoke ly

Details Isolated nonapeptides which bind to HLA molecules and provoke ly Isolated nonapeptides which bind to HLA molecules and provoke ly

1994-12-13

2000-03-07

Chan, Christina Y.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

8 to 10 amino acid residues in defined sequence

530300, 530385, 4241851, C07K 704, A61K 3702

Patent

active

060342145

ABSTRACT:
The invention involves the reception of particular nonapeptides by HLA molecules. The nonapeptides are derived from expression products of the MAGE gene family. The resulting complexes are identified by cytolytic T cells. Such recognition may be used in diagnostics, or therapeutically.

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Smilek, D. et al., PNAS 88:9633-9637, A single amino acid change in a myelin basic protein peptide confers the capacity to prevent rather than induce experimental autoimmune encephalomyelitis, Nov. 1991.
Ochoa-Garay, J. et al., Mol. Immunol. 34:273-281, The ability of pepties to induce cytotoxic T cells in vitro does not strongly correlate with their affinity for the H-2L-d molecule: implications for vaccine design and immunotherapy, 1997.
Salgaller, M. L. et al., Cancer Immunol. Immunother. 39:105-116, Generation of specific anti-melanoma reactivity by stimulation of human tumor-infiltrating lymphocytes with MAGE-1 synthetic peptide, 1994.

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