Isolated nona- and decapeptides which bind to HLA molecules, and

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 8 to 10 amino acid residues in defined sequence

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530300, 514 15, 4241851, 4242771, C07K 412, C07K 704

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active

06025470&

ABSTRACT:
Nonapeptides and decapeptides which bind to HLA molecules and provoke proliferation of cytolytic T cells are disclosed. The decapeptides terminate in Valine, and are restricted in their first three amino acid positions. Other useful nonapeptides are also disclosed.

REFERENCES:
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van der Bruggen et al., "a peptide encoded by human gene MAGE-3 and presented by HLA-A2 induces cytolytic T lymphocytes that recongize tumor cells expressming MAGE-3", Eur. J. Immunol. 24: 3038-A2 (1994).
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