Isolated metallopolypeptide: compositions and synthetic methods

Details Isolated metallopolypeptide: compositions and synthetic methods Isolated metallopolypeptide: compositions and synthetic methods

1993-12-09

1995-04-18

Hill, Jr., Robert J.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Insulin; related peptides

530300, 530326, A61K 3702, A61K 3726, C07K 500, C07K 700

Patent

active

054080363

ABSTRACT:
This invention contemplates an isolated metallopolypeptide comprising a polyvalent metal ion coordinately linked to 2 to about 8 polypeptide binding ligands, wherein at least 2 of said polypeptide binding ligands are covalently bonded to a linear amphiphilic peptide. The linear amphiphilic peptide has an alpha-helix, beta-sheet or beta-turn conformation. This invention further contemplates a metal ion-assisted, self-assembly method for producing a metallopolypeptide.

REFERENCES:
patent: 4849505 (1989-07-01), Stavrianopoulos
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J. Berg., Proc. Natl. Acad. Sci., vol. 85, pp. 99-102, 1988.
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Ghadiri et al, J. Am. Chem. Soc., vol. 112, pp. 9633-9635, 1990.
Ghadiri et al., "Peptide Architecture. Design of Stable .alpha.-Helical Metallopeptides via a Novel Exchange-Inert Ru.sup.III Complex", J. Am. Chem. Soc., 112:9633-9635 (1990).
Schiffer et al., "Use of Helical Wheels to Represent the Structures of Proteins and to Identify Segments with Helical Potential", Biophysical Journal, 7:121-135 (1967).
International Search Report, PCT/US91/07248.
Kemp et al., Tetrahedron Lett., 29(39):4931-4934 (1988).
Tainer et al., Nature, 306:284-287 (1983).
Felix et al., J. Pep. Prot. Res., 32:441-454 (1988).
Ghadiri et al., "Approaches Toward Total Synthesis of Artificial Receptors and Proteins", Scientific Report 1988-89, vol. 15 of the Research Institute of Scripps Clinic, p. 35.
Ghadiri et al., "Design and Synthesis of Artificial Proteins, Receptors, and Enzymes", Scientific Report 1989-90, vol. 16 of the Research Institute of Scripps Clinic, pp. 172-173.
Ghadiri et al., "Secondary Structure Nucleation in Peptides. Transition Metal Ion Stabilized .alpha.-Helics", J. Am. Chem. Soc., 112:1630-1632 (1990).

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