Isolated melanin-like substance and method for producing the sam

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Using a micro-organism to make a protein or polypeptide

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435 711, 435108, 43525234, 4352536, 4353201, 435975, C12N 120, C12N 902, C12P 2106

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active

060905883

ABSTRACT:
The production of a melanin-like compound by introducing an inactivated virus into a culture of bacteria is disclosed. After introduction, the inactivated virus causes a phenotypic change in the bacteria. When introduced into a media containing tyrosine, these modified bacteria produce a melanin-like compound, pyomelanin. The bacteria will continue to produce pyomelanin until they are removed from the tyrosine source.

REFERENCES:
patent: 5474933 (1995-12-01), Weiner et al.
patent: 5846531 (1998-12-01), Weiner et al.
Kotob et al. Homogentisic Acid Is the Primary Precursor of Melanin Synthesis in Vibrio cholerae, a Hyphomonas Strain, and Shewanella colwelliana. Appl. Environ. Microbiol. Apr. 1995, vol. 61, Nos. 4, pp. 1620-1622, see entire document.
Coon et al. Homogentisic Acid is the Product of MelA, Which Mediates Melanogenesis in the Marine Bacterium Shewanella colwelliana. D. Appl. Environ Microbiol. Aug. 1994, vol. 60, No. 8, pp. 3006-3010, see entire document.
Studier et al. Use of T7 Polymerase to Direct Expression of Cloned Genes. Methods Enzymol. 1990, vol. 185, pp. 60-89, especially pp. 83-85.

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