Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Reexamination Certificate
2007-06-26
2007-06-26
Belyavskyi, Michail A. (Department: 1644)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Reexamination Certificate
active
10129873
ABSTRACT:
The invention concerns a protein present at the surface of hematopoietic stem cells of the lymphoid cell line and mature NK cells, the corresponding isolated cDNA sequence and their uses as marker of said cells and for preparing antibodies directed against said protein. The invention also concerns the uses of said antibodies for selecting cells expressing at their surface said protein. Said isolated protein has a structure (a) comprising an extracellular domain located between positions 21 and 152, five transmembrane domains located between positions 153 and 295 and a cytoplasmic domain located between positions 296 and 350, with reference to the sequence SEQ ID NO:2; an apparent molecular weight of about 36 to 38 kDa, and its precursor, which comprises in N-terminal of structure (a), a signal sequence of 20 amino acids, is selected in the group consisting of the protein of SEQ ID NO:2, and the proteins having an amino acid sequence having at least 70% identity or at least 85% similarity and preferably at least 95% identity or at least 99% similarity with the sequence SEQ ID NO:2.
REFERENCES:
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Derwent Publ.; Accession No. V59687, Jan. 19, 1999 WO9839448: “Human secreted protein gene 177 clone HE9CM64”; XP002147597 99.2% identity in 1499 bp overlap with SeqldNo. 1 abstract.
Derwent Publ.; Accession No. W74904; Jan. 25, 1999 WO9839448: “Human secreted protein encoded by gene 177 clone HE9CM64”; XP002147598 99.1% identity in 350 aa overlap with SeqIdNo. 2 abstract.
Derwent Publ.; Accession No. V43608; Sep. 24, 1998; J. Escobedo, et al. “Human secreted protein 8 encoding DNA”; XP002147599 99.3% identity in 1149 bp overlap with SeqIdNo. 1 abstract.
Derwent Publ.; Accession No. W63688; Sep. 24, 1998; J. Escobedo, et al. “Human secreted protein 8”; XP002147600 99.6% identity in 254 aa overlap with SeqIdNo. 2 abstract.
Derwent Publ.; Accession No. X97785; Sep. 13. 1999; L. Bougueleret, et al. “Extended human secreted protein coding sequence, SeqIdNo. 350”; XP002147601 98.9% identity in 973 bp overlap with SeqIdNo. 1 abstract.
Derwent Publ.; Accession No. Y36101; Sep. 13, 1999; L. Bougueleret, et al. “Extended human secreted protein sequence, SeqIdNo. 486”; XP002147602 97.1% identity in 209 aa overlap with SeqIdNo. 2 abstract.
Swall Database; EBI, Hinxton, U.K.; Accession No. Q9Y3U9, Nov. 1, 1999; K. Koehrer, et al. “Hypothetical 34.9kDa protein”; XP00214605 cited in the application 99.365% identity in 315 aa overlap with SeqIdNo. 2 abstract.
Ernest Database; EBI, Hinxton, U.K.; Accession No. AW106427, Oct. 21, 1999; M. Marra, et al “Mus musculus cDNA clone IMAGE:2225799 5′ similar to WP:Y53C12A.3 CEI4888”; XP002147606 cited in application 97.826% identity in 506 nt overlap with SeqIdNo. 3 abstract.
Derwent Publ.; Accession No. A16633; Jun. 16, 2000; K. Jacobs, et al., “Human secreted protein clone py35—1 nucleotide sequence SeqIdNo. 31”; XP002147603 99.2% identity in 1424 bp overlap with SeqIdNo. 1 abstract.
Derwent Publ.; Accession No. Y94913, Jun. 16, 2000, K. Jacobs et al., “Human secreted protein clone py35—protein sequence SeqIdNo. 32”; XP002147604 identity in 315 aa overlap with SeqIdNo. 2 abstract.
Kirszenbaum Marek
Le Discorde Magali
Prost Stéphane
Belyavskyi Michail A.
Commissariat a l''Energie Atomique
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