Isolated, MAGE-3 derived peptides which complex with HLA-A2 mole

Details Isolated, MAGE-3 derived peptides which complex with HLA-A2 mole Isolated, MAGE-3 derived peptides which complex with HLA-A2 mole

1994-06-17

1997-01-07

Cunningham, Thomas M.

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Animal or plant cell

4241851, 4242771, 435 724, 4352402, 530328, 530395, 530828, A61K 3808, C07K 1482, C12N 506

Patent

active

055914306

ABSTRACT:
Tumor rejection antigens derived from tumor rejection precursor MAGE-3 have been identified. These "TRAS" bind to the MHC-class I molecule HLA-A2, and the resulting complexes stimulate the production of cytolytic T cell clones which lyse the presenting cells. The peptides and complexes may be used diagnostically, therapeutically, and as immunogens for the production of antibodies, or as targets for the generation of cytolytic T cell clones.

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Coulie et al., "A New Gene Coding For Differentiation Antigen Recognized by Autologous Cytolytic T Lymphocytes on HLA-A2 Melanomas", J. Exp. Med. 180: 35-42 (Jul., 1994) (Not Prior Art).
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