Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Hormones – e.g. – prolactin – thymosin – growth factors – etc.
Patent
1992-01-27
1994-01-18
Hill, Jr., Robert J.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Hormones, e.g., prolactin, thymosin, growth factors, etc.
530413, 5303891, 5303892, C07K 1300
Patent
active
052801098
ABSTRACT:
The invention relates to large latent complexes of TGF-.beta.2 and TGF-.beta.3, and methods for Isolating these. The complex consists of a dimerized form of TGF-.beta.2 or TGF-.beta.3, the appropriate latency associated peptide, and the latent TGF-.beta.1 binding protein, referred to as LTBP. Also described is a protein which binds to all of TGF-.beta.1, TGF-.beta.2 and TGF-.beta.3, but is immunologically distinct from LTBP, referred to as LTBP-2.
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Heldin Carl-Henrik
Miyazono Kohei
Olofsson Anders
Cermak Shelly Guest
Hill Jr. Robert J.
Ludwig Institute for Cancer Research
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