Isolated islet beta-cell two-pore domain potassium channel

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C530S300000, C514S012200, C424S198100

Reexamination Certificate

active

07053180

ABSTRACT:
The present invention provides polynucleotides encoding potassium channels as well as methods of using the potassium channels to treat and diagnose diabetes and a predisposition for diabetes.

REFERENCES:
patent: 5744594 (1998-04-01), Adelman et al.
patent: 6309855 (2001-10-01), Duprat et al.
patent: 6680180 (2004-01-01), Jegla
patent: 2002/0173636 (2002-11-01), Chen
patent: 2002-233369 (2002-08-01), None
patent: WO 02/12340 (2002-02-01), None
patent: WO 02/12340 (2002-02-01), None
patent: WO 02/053730 (2002-07-01), None
Skolnick et al. From genes to protein structure and function: novel applications of computational approaches in the genomic era. Trends in Biotech 18(1): 34-39, 2000.
Bork, A. Powers and pitfalls in Sequence analysis: the 70% hurdle. Genome Res 10: 398-400, 2000.
Doerks et al. Protein annotation: detective work for function prediction. Trends in Genetics 14(6): 248-250, 1998.
Smith et al. The challenges of genome sequence annotation or “The devil is in the details”. Nature Biotech 15: 1222-1223, 1997.
Brenner, S.E. Errors in genome function. Trends in Genetics 15(4): 132-133, 1999.
Bork et al. Go hunting in sequence databases but watch out for the traps. Trends in Genetics. 12(10): 425-427, 1996.
Wells. J.A. Additivity of mutational effects in proteins. Biochemistry 29 (37): 8509-8517, 1990.
Ngo et al. Computational complexity, protein structure prediction, and the Levinthal paradox. The Protein Folding Problem and Tertiary Structure Prediction, pp. 492-495, 1994.
Han et al. Functional properties of four splice variants of a human pancreatic tandem-pore K+ channel, TALK-1 Am J Physiol Cell Physiol. 285(3):C529-C538, 2003.
Huopio et al. K(ATP) channels and insulin secretion disorders. Am J Physiol Endocrinol Metab. 283(2):E207-E216, 2002.
Koster et al. Hyperinsulinism induced by targeted suppression of beta cell KATP channels. Proc Natl Acad Sci U S A 99(26):16992-16997, 2002.
Zhou et al. Overexpression of repressive cAMP response element modulators in high glucose and fatty acid-treated rat islets. A common mechanism for glucose toxicity and lipotoxicity? J Biol Chem. 278(51):51316-51323, 2003.
Lehmann-Horn et al. Voltage-gated ion channels and hereditary disease. Physiol Rev 79(4): 1317-1372, 1999.
Ashcroft, Frances, M.; “Ion Channels and Disease”; 2000.Academic Press, pp. 155-156.
Girard, Christophe et al.; “Genomic and Functional Characteristics of Novel Human Pancreatic 2P Domain K♦Channels”; 2001,Biochemical and Biophysical Research Communications, vol. 282, pp. 249-256.
Ketchem, Karen A. et al.; “A new family of outwardly rectifying potassium channel proteins with two pore domains in tandem”; 1995,Nature, vol. 376, pp. 690-695.
Kunkel, Maya T. et al.; “Mutants of a Temperature-Sensitive Two-P Domain Potassium Channel”; 2000,The Journal of Neuroscience, vol. 20, No. 20, pp. 7517-7524.
Lesage, Florian et al.; “Molecular and functional properties of two-pore-domain potassium channels”; 2000,Am. J. Physiol. Renal Physiol., vol. 279, pp. F793-F801.
Williams, S.; “Direct Submission”; Accession AL 136087, 2 pages, Sep. 5, 2000.
Williams, S.; “Dirct Submission”; Accession CAC07336, 2 pages, Sep. 5, 2000.
Lesage, Florian et al.; “Molecular and functional properties of two-pore-domain potassium channels”; 2000,Am J Physiol Renal Physiol, vol. 279, pp. F793-F801.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Isolated islet beta-cell two-pore domain potassium channel does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Isolated islet beta-cell two-pore domain potassium channel, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Isolated islet beta-cell two-pore domain potassium channel will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3611540

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.