Isolated human ras-like proteins, nucleic acid molecules...

Details Isolated human ras-like proteins, nucleic acid molecules... Isolated human ras-like proteins, nucleic acid molecules...

2005-11-29

2005-11-29

Canella, Karen A. (Department: 1642)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C435S069100, C435S320100, C435S325000, C435S252300, C435S254110, C536S023500, C536S024500

Reexamination Certificate

active

06969588

ABSTRACT:
The present invention provides amino acid sequences of polypeptides that are encoded by genes within the human genome, the Ras-like protein polypeptides of the present invention. The present invention specifically provides isolated polypeptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the Ras-like protein polypeptides, and methods of identifying modulators of the Ras-like protein polypeptides.

REFERENCES:
patent: WO 99 58670 (1999-11-01), None
patent: WO 02 10217 (2002-02-01), None
Verma et al (Nature, 1997, vol. 389, pp. 239-242).
Eck et al (Gene-Based Therapy, In: The Pharmacological Basis of Therapeutics, Goodman and Gilman, Ed.s, 1996, pp. 77-101).
Orkin et al state (“Report and Recommendation of the Panel to Assess the NIH investment in Research on Gene Therapy”, NIH, 1995).
Houdebine, Journal of Biotechnology, 1994, vol. 34, pp. 269-287.
St. Croix B. et al. “Genes Expressed in Human Tumor Endothelium.” Science. vol. 289, No. 5482, Aug. 18, 2000, pp. 1197-1202, XP002222041.
Falk Jeffrey D. et al. “Rhes: A Striatal-Specific Ras Homolog Related to Dexrasl.” Journal of Neuroscience Research. vol. 57, No. 6, pp. 782-788. XP009001294.
Adachi J. et al. “Mus Musculus Adult Make Testis cDNA, RIKEN Full-Length Enriched Library, Clone: 49305262B11: Homolog to REHS Protein, Full Insert Sequence.” Database accession, No. AK015898. XP002222042.
International Search Report dated Dec. 11, 2002.
Results of BLAST search of SEQ ID No. 2 against Derwent (FastAlert and GeneSeqP) and NCBI (pataa) protein patent databases on Jun. 26, 2003.

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