Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues
Patent
1997-12-12
2000-07-25
McKelvey, Terry
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
530324, 530325, 530326, 530327, 530328, 530350, C07K 1447, C07K 412, C07K 700
Patent
active
060937955
ABSTRACT:
The present invention relates to novel human Prt1 (hPrt1) and eIF4G-like (p97) proteins which are involved in eukaryotic transcription. In particular, isolated nucleic acid molecules are provided encoding the human hPrt1 and p97 proteins. hPrt1 and p97 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of hPrt1 and p97 activity. Also provided are therapeutic methods for treating disease states associated with the hPrt1 and p97 proteins.
REFERENCES:
patent: 5002874 (1991-03-01), Kaufman
Berendsen, Science, Vo. 282: pp. 642-643, Oct. 1998.
Caldwell, Yakubutsu Dotai (Xenobiotic Metabolism and Disposition), vol. 11(1): pp. 119-125, 1996.
Genbank Report, Imataka, H. et al., Accession No. U73824. (Mar. 1997).
Genbank Report, Yamanaka, S. et al., Accession No. U76111. (Mar. 1997).
Genbank Report, Levy-Strumpf, N. et al., Accession No. X89713. (Mar. 1997).
Genbank Report, Methot, N. et al., Accession No. U62583. (Jan. 1997).
Genbank Report, Chaudhuri, J. et al., Accession No. U78525. (Feb. 1997).
Imataka, H. et al., "A new translational regulator with homology to eukaryotic translation initiation factor 4G," EMBO J. 16:817-825 (Feb. 1997).
Levy-Strumpf, N. et al., "DAP-5, a Novel Homolog of Eukaryotic Translation Initiation Factor 4G Isolated as a Putative Modulator of Gamma Interferon-Induced Programmed Cell Death," Mol. Cell. Biol. 17:1615-1625 (Mar. 1997).
Shaughnessy Jr., J.D. et al., "cDNA Cloning, Expression Analysis, and Chromosomal Localization of a Gene with High Homology to Wheat eIF-(iso)4F and Mammalian eIF-4G," Genomics 39:192-197 (Jan. 1997).
Yamanaka, S. et al., "A novel translational repressor mRNA is edited extensively in livers containing tumors caused by the transgene expression of the apoB mRNA-editing enzyme," Genes & Develop. 11:321-333 (Feb. 1997).
Abramson, R. et al., "Initiation Factors That Bind mRNA, A Comparison of Mammalian Factors With Wheat Germ Factors," J. Biol. Chem 263(11):5462-5467 (1988).
Acland, P. et al., "Subcellular fate of the Int-2 oncoprotein is determined by choice of initiation codon," Nature 343(6259):662-665 (1990).
Adams, M. et al., "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence," Nature 377(6547 Suppl):3-174 (Sep. 1995).
Allen, M. et al., "Isolation and Sequence of the cDNAs Encoding the Subunits of the Isozyme Form of Wheat Protein Synthesis Initiation Factor 4F," J. Biol. Chem. 267(32):23232-23236 (1992).
Beauparlant, P. et al., "The Role of the C-terminal Domain of I.kappa.B.alpha. in Protein Degradation and Stabilization," J. Biol. Chem. 271(18):10690-10696 (May 1996).
Behlke, J. et al., "Structure of initiation factor eIF-3 from rat liver, Hydrodynamic and electron microscopic investigations," Eur. J. Biochem. 157(3):523-530 (1986).
Benne, R. and J. Hershey, "Purification and characterization of initiation factor IF-E3 from rabbit reticulocytes," Proc. Natl. Acad. Sci. USA 73(9):3005-3009 (1976).
Benne, R. et al., "Protein Synthesis Initiation Factors from Rabbit Reticulocytes: Purification, Characterization, and Radiochemical Labeling," Meth. Enzymology 60:15-35 (1979).
Beretta, L. et al., "Rapamycin blocks the phosphorylation of 4E-BP1 and inhibits cap-dependent initiation of translation," EMBO J. 15(3):658-664 (Feb. 1996).
Birney, E. et al., "Analysis of the RNA-recognition motif and RS and RGG domains: conservation in metazoan pre-mRNA splicing factors," Nucleic Acids Research 21(25):5803-5816 (1993).
Blanar, M. and W. Rutter, "Interaction Cloning: Identification of a Helix-Loop-Helix Zipper Protein That Interacts with c-Fos," Science 256:1014-1018 (1992).
Boeck, R. and D. Kolakofsky, "Positions +5 and +6 can be major determinants of the efficiency of non-AUG initiation codons for protein synthesis," EMBO J. 13(15):3608-3617 (1994).
Browning, K. et al., "Determination of the Amounts of the Protein Synthesis Initiation and Elongation Factors in Wheat Germ," J. Biol. Chem. 265(29):17967-17973 (1990).
Brown-Luedi, M. et al., "Protein Synthesis Initiation Factors from Human HeLa Cells and Rabbit Reticulocytes Are Similar: Comparison of Protein Structure, Activities, and Immunochemical Properties," Biochem. 21(18):4202-4206 (1982).
Bruening, W. and J. Pelletier, "A Non-AUG Translational Initiation Event Generates Novel WT1 Isoforms," J. Biol. Chem. 271(15):8646-8654 (Apr. 1996).
Bugler, B. et al., "Alternative Initiation of Translation Determines Cytoplasmic or Nuclear Localization of Basic Fibroblast Growth Factor," Mol. Cellular Biol. 11(1):573-577 (1991).
Burd, C. and G. Dreyfuss, "Conserved Structures and Diversity of Functions of RNA-Binding Proteins," Science 266:615-621 (1994).
Chambers, J. et al., "Genomic Structure and Amino Acid Sequence Domains of the Human La Autoantigen," J. Biol. Chem. 263(34):18043-18051 (1988).
Charest, A. et al., "Murine protein tyrosine phosphatase-PEST, a stable cytosolic protein tyrosine phosphatase," Biochem. J. 308(Pt 2):425-432 (Jun. 1995).
Chaudhuri, J., "Role of Protein Factors In Initiation Of Translation In Eukaryotic Cells," Dissertation Abstracts International 58(5B):2266 No. AAR9717861 (Dec. 1996).
Chaudhuri, J., "Biochemical Characterization of Mammalian Translation Initiation Factor 3 (eIF3)," J. Biol. Chem. 272(49):30975-30983 (Dec. 1997).
Danaie, P. et al., "Isolation of a Protein Complex Containing Translation Initiation Factor Prt1 from Saccharomyces cerevisiae," J. Biol. Chem. 270(9):4288-4292 (Mar. 1995).
Duncan, R. et al., "Regulated Phosphorylation and Low Abundance of HeLa Cells Initiation Factor eIF-4F Suggest a Role in Translational Control," J. Biol. Chem. 262(1):380-388 (1987).
Evans, D. et al., "Mutational Analysis of the Prt1 Protein Subunit of Yeast Translation Initiation Factor 3," Mol. Cellular Biol. 15(8):4525-4535 (Aug. 1995).
Feinberg, B. et al., "Analysis of Temperature-sensitive Mutant ts 187 of Saccharomyces cerevisiae Altered in a Component Required for the Initiation of Protein Synthesis," J. Biol. Chem. 257(18):10846-10851 (1982).
Florkiewicz, R. and A. Sommer, "Human basic fibroblast growth factor gene encodes four polypeptides: Three initiate translation from non-AUG codons," Proc. Natl. Acad. Sci. USA 86(11):3978-3981 (1989).
Garcia-Barrio, M. et al., "GCD10, a translational repressor of GCN4, is the RNA-binding subunit of eukaryotic translation initiation factor-3," Genes and Development 9(14):1781-1796 (Jul. 1995).
Gorman, C. et al., "Recombinant Genomes Which Express Chloramphenicol Acetyltransferase in Mammalian Cells," Mol. Cellular Biol. 2(9):1044-1051 (1982).
Goumans, H. et al., "The Role of eIF-4C in Protein Synthesis Initiation Complex Fromation," Biochimica et Biophysica Acta 608(1):39-46 (1980).
Goyer, C. et al., "TIF4631 and TIF4632: Two Yeast Genes Encoding the High-Molecular-Weight Subunits of the Cap-Binding Protein Complex(Eukaryotic Initiation Factor 4F) Contain an RNA Recognition Motif-Like Sequence and Carry Out an Essential Function," Mol. Cellular Biol. 13(8):4860-4874 (1993).
Grunert, S. and R. Jackson, "The immediate downstream codon strongly influences the efficiency of utilization of eukaryotic translation initiation codons," EMBO J. 13(15):3618-3630 (1994).
Haghighat, A. et al., "Repression of cap-dependent translation by 4E-binding protein 1: competition with p220 for binding to eukaryotic initiation factor-4E," EMBO J. 14(22):5701-5709 (Nov. 1995).
Hanic-Joyce, P. et al., "Molecular Characterization of the Yeast PRT1 Gene in Which Mutations Affect Translation Initiation and Regulation of Cell Proliferation," J. Biol. Chem. 262(6):2845-2851 (1987).
Hannig, E., "Protein synthesis in eukaryotic organisms: new insights into the function of translation initiation factor eIF-3," BioEssays 17(11):915-919 (Nov. 1995).
Hann, S. et al., "A Non-AUG Translational Initiation in c-myc Exon 1 Generates an N-terminally Distinct Protein Whose Synthesis Is Disrupted in Burkitt's Lymphomas," Cell 52(2):185-195 (1988).
Hann, S. e
Methot Nathalie
Olsen Henrik Steen
Rom Eran
Ruben Steven Michael
Sonenberg Nahum
Human Genome Sciences Inc.
McGill University
McKelvey Terry
LandOfFree
Isolated human Prt1 protein does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Isolated human Prt1 protein, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Isolated human Prt1 protein will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1337335